|
|
|
| Predictive Value of Thrombopoietin and Hypoxia Inducible Factor-1α in High Risk Infants with Cerebral Palsy |
| YANG Guan-shan, WANG Wan-li |
| Ankang Hospital of Traditional Chinese Medicine,Ankang Shaanxi 725000 |
|
|
|
|
Abstract 【Objective】 To investigate the predictive diagnostic value of thrombopoietin (TPO) and hypoxia inducible factor-1α(HIF-1α) in high-risk infants with cerebral palsy (CP).【Methods】 A total of 120 cases of CP high-risk infants was selected as the research object, and 35 cases of healthy newborns in the same period were selected as the control group. The high-risk infants were followed up until CP was diagnosed or excluded. According to the follow-up results, CP high-risk infants were divided into CP Group (n=36) and non CP Group (n=73); CP Group was divided into mild subgroup (n=14), moderate subgroup (n=10) and severe subgroup (n=12). The levels of serum TPO and HIF-1αin each group were compared, and the ROC curve was drawn to analyze the diagnostic value of serum TPO and HIF-1αfor CP. Spearman linear correlation was used to analyze the correlation between serum TPO and HIF-1αlevels in CP high-risk infants. 【Results】 The serum TPO level in CP Group was higher than that in control group but lower than that in non CP Group; there were significant differences among control group, non CP Group, CP Group and each subgroup (P<0.05). The serum HIF-1 α level in CP Group was higher than that in control group and non CP Group, and that in non CP Group was higher than that in control group. There were significant differences among control group, non CP Group, CP Group and subgroups with different disease severity (P<0.05). ROC curve analysis showed that the area under the curve (AUC) of serum TPO in the diagnosis of CP was 0.785, the sensitivity was 77.80%, the specificity was 79.45%, and the best cut-off value was 596.75 pg / ml; the AUC of serum HIF-1αin diagnosing CP was 0.779, the sensitivity was 80.06%, the specificity was 80.56%, and the best cut-off value was 5.72 ng / ml. Spearman linear correlation analysis showed that there was a negative correlation between serum TPO and HIF-1α(r=-0.334,P<0.001).【Conclusion】 The levels of serum TPO and HIF-1αin high-risk infants with CP are higher than those in healthy newborns. The changes of serum TPO and HIF-1αlevels play an important role in the pathogenesis of CP.
|
|
Received: 24 January 2019
|
|
|
|
|
|
[1] 李晓捷.中国脑性瘫痪康复的现状、挑战及发展策略[J].中国康复医学杂志,2016,31(1):6-8.
[2] 曾志,王志峰.TPO对缺氧缺血新生小鼠神经保护作用的实验研究[J].医学理论与实践,2017,30(11):1561-1564.
[3] 王依凝,安帅.低氧诱导因子1α对周围神经系统损伤修复的影响[J].医学综述,2018,24(3):434-437+443.
[4] 黄真,杨红,陈翔,等.中国脑性瘫痪康复指南(2015):第二部分[J].中国康复医学杂志,2015,30(8):858-866.
[5] 魏环,关丽君.健脑益智散联合康复训练对脑瘫患儿血清IGF-1及炎性细胞因子影响研究[J].辽宁中医药大学学报,2017,19(6):122-124.
[6] 洪永锋,徐军,沈显山, 等.不同时机开始康复干预对2岁前脑瘫高危儿粗大运动疗效的影响[J].中华物理医学与康复杂志,2017,(9):686-691.
[7] Zhang K, Dai Z, Liu R, et al. Icaritin provokes serum thrombopoietin and down regulates thrombopoietin/MPL of the bone marrow in a mouse model of immune thrombocytopenia[J].Mediators Inflamm,2018,4:1-10.
[8] Wu W, Zhong W, Lang B, et al. Thrombopoietin could protect cerebral tissue against ischemia-reperfusion injury by suppressing NF-κB and MMP-9 expression in rats[J].Int J Med Sci,2018,15(12):1341-1348.
[9] 卢林民,宋学栋,罗宁.磁共振成像联合血清缺氧诱导因子-1诊断新生儿缺血缺氧性脑病的价值[J].解放军医药杂志,2018,30(2):41-45.
[10] Deng W, Feng X, Li X, et al.Hypoxia-inducible factor 1 in autoimmune diseases[J].Cell Immunol,2016,303:7-15.
[11] 刘蕾,许婉华,周丽霞,等.血小板生成素水平在急性炎症状态的变化及其意义探讨[J].中国实验血液学杂志,2017,25(3):860-865.
[12] 董新宇,文芳,唐从峰,等.促血小板生成素对预测脑瘫高危儿的意义[J].卒中与神经疾病,2006,13(2):103-105. |
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(7): 1450-1452. |
|
|
|
|
2020, Vol. 37 
