TGF-β蛋白、AGEs在糖尿病性白内障患者晶状体前囊膜组织和血清中的表达及其意义

doi:10.3969/j.issn.1671-7171.2020.10.017

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (0 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】 To investigate the expression levels and significance of transforming growth factor β(TGF-β) and advanced glycation end products (AGEs) in anterior capsule tissue of lens and serum of diabetic patients with cataract. 【Methods】 Sixty-seven patients with diabetes mellitus complicated with cataract (the observation group) and 50 patients with simple cataract (the control group) were selected from January 2018 to January 2019 in our hospital. The expression of TGF-β protein in anterior capsular tissue of lens was detected by Western blot and the level of AGEs and HbA1c in serum was detected by ELISA. 【Results】 The relative expression of TGF-β protein in the lens anterior capsular tissue and serum AGEs of the observation group were (0.982±0.172) and (18.82±1.82)g/L, respectively, which were significantly higher than those of the control group (0.563±0.180) and (10.95±2.00) g/L, respectively. The differences were statistically significant (P<0.05). The serum AGEs level of patients with HbA1c ≥6.5% in the observation group was (19.96±1.88)g/L, which was significantly higher than that of patients with HbA1c <6.5% (17.78±1.89) g/L, the difference was statistically significant (P<0.05). 【Conclusion】 In diabetic patients with cataract, the levels of TGF-β in lens anterior capsule tissue and AGEs in serum increased. AGEs are related to glycosylated hemoglobin, TGF-β and AGEs may play a role in the process of diabetic cataract.

Key words： Diabetes Mellitus/CO Cataract Transforming Growth Factors Lens Capsule,Crystalline

Received: 05 May 2019

PACS:

R776.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	SONG Chun-hua
	HE Wei-quan

Cite this article:

SONG Chun-hua,HE Wei-quan. Influence of TGF-β Protein and AGEs Expression on Development of Cataract in Diabetic Patients[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(10): 1497-1499.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.10.017 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I10/1497

[1] 佚名. 糖尿病并发白内障患者晶状体前囊膜组织TGF-β表达、血清AGEs水平变化及意义[J].山东医药, 2018, 58(32):85-87.
[2] 张南,许家骏,赵静如,等.视清饮对瘀热阻络型白内障合并非增殖期糖尿病视网膜病变患者的疗效[J].中华中医药杂志, 2018,11(1):386-389.
[3] 姜凌峰, 石栋, 阎启昌. 2型糖尿病合并皮质性白内障患者房水中Txnip、Trx的定量检测及相关性分析[J].眼科新进展, 2017, 37(8):736-738.
[4] 李筱荣, 刘巨平. 重视糖尿病眼部并发症的诊断和治疗[J].中华实验眼科杂志, 2017, 35(7):577-587.
[5] 刘倚河, 廖瑞真, 刘舜辉,等. 老年性白内障的超声分型与临床分期关系[J].中国临床医学影像杂志, 2020,31(2):133-134.
[6] Srinivasan S, Raman R, Swaminathan G, et al. Incidence, progression, and risk factors for cataract in type 2 diabetes [J].Invest Ophthalmol Vis Sci,2017, 58(13):5921-5929.
[7] Peterson SR, Silva PA, Murtha TJ, et al. Cataract surgery in patients with diabetes: management strategies [J].Semin Ophthalmol,2018, 33(1):1-5.
[8] Lenfant C, Baz P, Degavre A, et al. Juvenile-onset diabetes and congenital cataract: "double-gene" mutations mimicking a syndromic diabetes presentation[J].Genes,2017, 8(11):309-313.
[9] 席亚慧, 刘红玲. RNA干扰技术干扰信号通路在后发性白内障防治中的应用[J].中华实验眼科杂志, 2017, 35(12):1126-1129.
[10] 岳秀娟,苏胜,王丽媛,等.长链非编码RNA-MIAT在转化生长因子β2诱导的晶状体上皮-间质转化中的作用[J].中华实验眼科杂志, 2018, 36(7):508-515.
[11] 魏菁, 张明华. 血清TGF-β_1、CTGF与增生性糖尿病视网膜病变的关系[J].中国现代医学杂志, 2018, 28(7):61-65.
[12] 孙梅艳. 土黄芪加六味地黄丸对肾小管上皮细胞TGF-β/Smads信号传导通路的影响[J].重庆医学, 2017,11(A01):74-75.