|
|
|
| Effect of Different Time Enteral Nutrition on Severe Acute Pancreatitis |
| BI Ning, WANG Jing, CHEN Hui |
| Huanggang Central Hospital,Huanggang,Hubei 438000,China |
|
|
|
|
Abstract 【Objective】 To compare the effect of enteral nutrition at different time on severe acute pancreatitis (SAP).【Methods】 One hundred and three patients with SAP in our hospital were randomly divided into early enteral nutrition group (EEN group,n=53) and delayed enteral nutrition group (DEN group,n=50). Enteral nutrition was started at 48 hours in the EEN group and 96 hours in the DEN group. The hospitalization time, abdominal pain relief time and spontaneous defecation time, mortality and complications of the EEN group and the DEN group were compared. The changes of nutritional indexes (albumin, prealbumin) and inflammatory indexes (C-reactive protein and procalcitonin) in peripheral blood of the two groups on the day 14th were compared.【Results】 The time of abdominal pain relief, the time of spontaneous defecation and the mortality rate during hospitalization in the EEN group were lower than those in the DEN group (P<0.05). The incidence of systemic inflammatory response syndrome (SIRS), intra-abdominal hypertension and pancreatic abscess complications in the EEN group was lower than that in the DEN group (P<0.05). Ten days after admission, the levels of albumin and prealbumin in the EEN group were lower than those in the DEN group, the difference was statistically significant (P<0.05); there was no significant difference in peripheral blood inflammatory indexes (C-reactive protein, procalcitonin) between the two groups (P>0.05).【Conclusion】 Early enteral nutrition support is conducive to the recovery of SAP patients, and can reduce the mortality and some complications.
|
|
Received: 29 September 2019
|
|
|
|
|
|
[1] 中华医学会外科学分会胰腺外科学组.急性胰腺炎诊治指南(2014)[J].中华外科杂志,2015,53(1):50-53.
[2] Tenner S, Baillie J, Dewitt J, et al. American college of gastroenterology guideline: management of acute pancreatitis[J].Am J Gastroenterol,2013, 108(9):1400-1415.
[3] 中华医学会消化病学分会胰腺疾病学组,中华胰腺病杂志编辑委员会,中华消化杂志编辑委员会.中国急性胰腺炎诊治指南(2013年,上海)[J].中华消化杂志,2013,33(4):217-222.
[4] 刘丕,吕农华.重症急性胰腺炎的营养治疗[J].临床内科杂志,2011,28(2):83-86.
[5] Besselink MG, Santvoort HCV, Boermeester MA, et al. Timing and impact of infections in acute pancreatitis[J].Br J Surg,2009, 96(3):267-273.
[6] Petrov MS . Enteral nutrition and the risk of mortality and infectious complications in patients with severe acute pancreatitis: a meta-analysis of randomized trials[J].Arch Surg, 2008, 143(11):1111-1117.
[7] 门婷婷.急性胰腺炎肠内营养现状及研究进展[J].滨州医学院学报,2016,39(2):130-132.
[8] 付云辉,文剑波,王桂良,等.早期肠内营养对重症急性胰腺炎患者细胞因子水平及内毒素的影响[J].世界华人消化杂志,2015,23(7):1174-1179.
[9] 彭富治,李卉.急性胰腺炎早期肠内营养研究进展[J].肠外与肠内营养,2017,24(4):249-252.
[10] 张鸣杰,张国雷,魏云海,等.早期肠内营养支持对重症急性胰腺炎患者腹内压的影响[J].肝胆胰外科杂志,2012,24(6):455-458.
[11] 王鹏旭,尚东.急性胰腺炎的国内外主要指南分析[J].肝胆胰外科杂志,2017,29(1):1-5. |
|
|
|
2020, Vol. 37 
