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| Effect of Dexmedetomidine and Sufentanil on Postoperative Patient-controlled Intravenous Analgesia in Patients with Colon Cancer |
| YANG Xiao-yan, ZHU Guo-han, TAN Ai-ping |
| Department of Anesthesiology, the People's Hospital of Suzhou New District, Suzhou Jiangsu, 215129 |
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Abstract 【Objective】 To investigate the effect of dexmedetomidine combined with sufentanil on pain and comfort of Patient-controlled Intravenous Analgesia (PCIA) in patients with colon cancer after laparoscopic surgery. 【Methods】 A total of 104 patients undergoing laparoscopic colon cancer radical mastectomy were selected from our hospital. They were randomly divided into the observation group and the control group with 52 cases in each. Patients in the observation group recieved dexmedetomidine combined with sufentanil for PCIA analgesia, while patients in the control group only received single-agent sufentanil PCIA. Postoperative pain, comfort, serum Cor, β-EP, PGE2, IL-6 and adverse reactions were compared between the two groups. 【Results】 The VAS scores of the observation group patients at the corresponding time points from 2 hours to 48 hours after surgery were lower than those of the control group (P<0.05). The BCS scores of the observation group patients at the corresponding time points were higher than those of the control group (P<0.05); At time immediately after surgery, there was no significant difference in serum Cor, β-EP, PGE2, and IL-6 levels between the two groups (P>0.05), while 24 hours after surgery, the levels of serum Cor, β-EP, PGE2, and IL-6 in the observation group were lower than those in the control group (P<0.05). During the implementation of analgesia, the incidence of adverse reactions in the observation group was 9.62% which was lower than that in the control group 21.15% (P<0.05). 【Conclusion】 The application of PCIA with both dexmedetomidine and sufentanil in patients with colon cancer after laparoscopic surgery has a better effect on improving patients' pain and comfort experience.
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Received: 05 June 2019
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2020, Vol. 37 
