Meta分析评价热毒宁注射液联合抗生素治疗儿童社区获得性肺炎的疗效及安全性

doi:10.3969/j.issn.1671-7171.2020.03.019

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Abstract 【Objective】 To evaluate the clinical efficacy and safety of Reduning injection combined with antibiotics in the treatment of children community acquired pneumonia by Meta-analysis. 【Methods】Randomized controlled trials were retrieved in Pubmed,Embase,CBM,CNKI,VIP and Wanfang database.Quality of the RCTs was evaluated strictly by using the Jadad quality evaluation method,statistical analysis was performed using Meta-analysis.【Results】 Finally, 8 articles were included in the study, the total number of cases was 2451. The results of meta analysis showed that: compared with the single antibiotic group, the combined drug group had more advantages in the total effective rate[WMD=-2.64,95%CI (-2.75,-2.54),P<0.0001], the disappearance time of cough [WMD=-0.96,95%CI (-1.18,-0.74),P<0.00001], asthma and sputum, the disappearance time of lung rale[WMD=-0.96,95%CI(-1.18,-0.74),P<0.05], the shadow absorption time of X-ray focus[WMD=-2.88,95%CI(-3.05,-2.71),P<0.00001], the disappearance time of respiratory shortness of breath[WMD=-1.26,95%CI(-1.32,-1.20),P<0.05] and the difference was statistically significant (P<0.05).【Conclusion】Reduning combined with antibiotics is safe and effective in the treatment of children's community-acquired pneumonia, but more high-quality large sample, multicenter, randomized, double-blind, controlled clinical trials are needed to further confirm.

Key words： Penumonia Community-acquired Infections Child

Received: 18 September 2019

PACS:

R725.631

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	LI Guo-ying
	CHEN Liang
	LIU Jun

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LI Guo-ying,CHEN Liang,LIU Jun. Meta Analysis to Valuate the Efficacy and Safety of Reduning Injection Combined with Antibiotics in the Treatment of Community Acquired Pneumonia in Children[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(3): 385-389.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.03.019 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I3/385

[1] 刘兴颖,刘根贤.儿童社区获得性肺炎病原菌及其耐药性变迁分析[J].中国卫生检验杂志,2017,27(11):1658-1664.
[2] 魏巍,王雪峰,吴振起,等.中医内外合治方案治疗社区获得性肺炎远期疗效观察[J].辽宁中医杂志,2019,46,(3):586-590.
[3] 中华中医药学会内科分会肺系病专业委员会.社区获得性肺炎中医诊疗指南(2011版)[J].中医杂志,2011,52(21):1883-1888.
[4] 常秀娟,张帅,江益平,等.从细胞因子风暴探讨热毒宁注射液抗大鼠急性肺损伤作用机制[J].中草药,2015,46(2):236-239.
[5] 中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.儿童社区获得性肺炎管理指南(2013修订)(下)[J].中华儿科杂志,2013, 51(11):856-862.
[6] 李铁辉.热毒宁与喜炎平注射液治疗急性上呼吸道感染的Meta分析[J].中国医药指南,2019,17(16):169-170.
[7] 陈欣华,陈草明,陈毓强.热毒宁联合头孢呋辛钠治疗儿童社区获得性肺炎120例临床观察[J].成都医学院学报,2009,4(2):117-119.
[8] 陈勇,蒋宇桐,杨慧敏.热毒宁治疗儿童社区获得性肺炎的随机对照双盲试验研究[J].云南中医学院学报,2015,38(4):73-77.
[9] 邓文学.热毒宁治疗儿童社区获得性肺炎的效果观察[J].中国临床新医学,2013,6(4):342-345.
[10] 潘文桥.中西药联合治疗儿童社区获得性肺炎70例[J].中国中医药现代远程教育,2011,9(21):117-118.
[11] 张寅娥.热毒宁注射液联合阿奇霉素静脉滴注治疗儿童社区获得性肺炎疗效观察[J].中国误诊学杂志,2012,12(16):4304-4305.
[12] 周双丽,白明伟.热毒宁联合阿奇霉素治疗儿童社区获得性肺炎[J].中国实用医刊,2011,38(20):101-102.
[13] 班洪芳,孙清.热毒宁佐治儿童社区获得性肺炎疗效观察[J].中外女性健康(下半月),2014,(12):310-315.
[14] 刘东凯,刘炜,安晓霞.头孢西丁钠联合热毒宁注射液治疗儿童获得性肺炎对照研究[J].临床心身疾病杂志,2018,24,(2):127-130.
[15] 康丹瑜,耿婷,丁岗,等.热毒宁注射液临床联用及药物相互作用的研究进展[J].中国药房,2017,28(2):276-279.
[16] 黄晓帅.热毒宁和利巴韦林治疗小儿急性上呼吸道感染的临床观察[J].北方药学,2018,15(1):122-123.
[17] 赵吟,邓彧斐.热毒宁注射液对儿童急性喉气管炎免疫功能及炎性反应的影响[J].世界中医药,2019,14(4):962-965.

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