Abstract【Objective】To investigate the expression and significance of Girdin and B-lycytoma-2(BCL-2) proteins in glioma tissues.【Methods】From March 2010 to January 2013, 53 patients with gliomas diagnosed and treated in our hospital were selected. The expression of Girdin and BCL-2 protein in gliomas and normal tissues adjacent to gliomas were detected by immunohistochemistry. The relationship between the expression level and the clinicopathological characteristics of patients and the total survival period was analyzed.【Results】The positive rates of Girdin and BCL-2 protein in gliomas were 60.38% (32 / 53) and 41.51% (22 / 53), which were significantly higher than those in normal tissues 5.66% (3 / 53) and 1.89% (1 / 53). The differences were statistically significant (P<0.05). The expression level of Girdin protein in gliomas was related to pathological grade, peritumoral edema and gross diameter of tumor (P<0.05); the expression level of Bcl-2 protein in gliomas was related to gender (P<0.05). The survival rate of patients with high expression of Girdin protein was significantly lower than that of patients with low expression (P<0.05), and there was no significant difference between patients with high expression of BCL-2 protein and patients with low expression of BCL-2 protein (P>0.05).【Conclusion】Girdin and BCL-2 protein are highly expressed in gliomas. Girdin protein is involved in the development of gliomas and has a negative impact on their prognosis.
CHEN A-jing,SUI Yu-ming,GOU Rong-bin, et al. Expression and Significance of Girdin and BCL-2 Protein in Glioma Tissue[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(2): 164-166.
[1] 赵云东, 孙冬弢, 陈振军. 过表达Cofilin-1对人胶质瘤细胞侵袭和增殖及凋亡的影响[J].医学临床研究, 2018, 35(9):1665-1668.
[2] Platten M, Wick W, Weller M. Malignant glioma biology: Role for TGF-β in growth, motility, angiogenesis, and immune escape[J].Microsc Res Tech,2015, 52(4):401-410.
[3] 李伟. Girdin、Bim蛋白在儿童肾母细胞瘤中的表达及其与临床病理的相关性[J].海南医学, 2016, 27(12):1939-1941.
[4] Fiskvik I, Beiske K, Delabie J,et al. Combining MYC, BCL2 and TP53 gene and protein expression alterations improves risk stratification in diffuse large B-cell lymphoma[J].Leuk Lymphoma,2015, 56(6):1742-1749.
[5] Nishimae K, Tsunoda N, Yokoyama Y, et al. The impact of Girdin expression on recurrence-free survival in patients with luminal-type breast cancer[J].Breast Cancer,2015, 22(5):445-451.
[6] Tomiyama L, Sezaki T, Matsuo M, et al. Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation[J].Oncogene,2015, 34(9):1141-1149.
[7] Weimin NI, Yan F, Lei T, et al. Girdin regulates the migration and invasion of glioma cells via the PI3K-Akt signaling pathway[J].Mol Med Rep,2015, 12(4):5086-5092.
[8] Chi H. miR-194 regulated AGK and inhibited cell proliferation of oral squamous cell carcinoma by reducing PI3K-Akt-FoxO3a signaling[J].Biomed Pharmacother,2015, 71(5):53-57.
[9] Hao NB, Tang B, Wang GZ, et al. Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-κB signaling pathway for gastric cancer metastasis[J].Cancer Lett,2015, 361(1):57-66.
[10] Wang H, Zhang J, Zhang M, et al. A systematic study of Girdin on cell proliferation, migration and angiogenesis in different breast cancer subtypes[J].Mol Med Rep,2017, 16(3):3351-3356.
[11] 陈丽, 张斌, 张艺, 等. 环磷酰胺联合柿叶乙酸乙酯部位对H22小鼠瘤组织抗氧化能力及Bcl-2,Bax蛋白表达的影响[J].中国实验方剂学杂志, 2015,21(15):120-123.
[12] 王俊玲, 余谦, 冯君平,等. 牛磺酸对氟致神经细胞内钙离子浓度和细胞凋亡改变的干预研究[J].毒理学杂志, 2016, 30(3):189-191.
[13] Pena JC, Thompson CB, Recant W, et al. Bcl-xL and Bcl-2 expression in squamous cell carcinoma of the head and neck[J].Cancer,2015, 85(1):164-170.
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(9): 1763-1765.
2020, Vol. 37 
