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| Expression and Significance of Girdin and BCL-2 Protein in Glioma Tissue |
| CHEN A-jing, SUI Yu-ming, GOU Rong-bin,et al |
| Department of Pathology, Beijing Boai Hospital of China Rehabilitation Research Center, Beijing 100068, China |
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Abstract 【Objective】To investigate the expression and significance of Girdin and B-lycytoma-2(BCL-2) proteins in glioma tissues.【Methods】From March 2010 to January 2013, 53 patients with gliomas diagnosed and treated in our hospital were selected. The expression of Girdin and BCL-2 protein in gliomas and normal tissues adjacent to gliomas were detected by immunohistochemistry. The relationship between the expression level and the clinicopathological characteristics of patients and the total survival period was analyzed.【Results】The positive rates of Girdin and BCL-2 protein in gliomas were 60.38% (32 / 53) and 41.51% (22 / 53), which were significantly higher than those in normal tissues 5.66% (3 / 53) and 1.89% (1 / 53). The differences were statistically significant (P<0.05). The expression level of Girdin protein in gliomas was related to pathological grade, peritumoral edema and gross diameter of tumor (P<0.05); the expression level of Bcl-2 protein in gliomas was related to gender (P<0.05). The survival rate of patients with high expression of Girdin protein was significantly lower than that of patients with low expression (P<0.05), and there was no significant difference between patients with high expression of BCL-2 protein and patients with low expression of BCL-2 protein (P>0.05).【Conclusion】Girdin and BCL-2 protein are highly expressed in gliomas. Girdin protein is involved in the development of gliomas and has a negative impact on their prognosis.
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Received: 25 October 2018
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2020, Vol. 37 
