GAS5在子痫前期患者血清及胎盘组织中的表达及其意义

doi:10.3969/j.issn.1671-7171.2020.02.011

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Abstract 【Objective】To investigate the expression and significance of growth arrest specific protein 5 (gas5) in serum and placenta of preeclampsia patients.【Methods】From January 2015 to December 2017, 43 preeclampsia patients (observation group) and 43 normal pregnant women (control group) were selected. Serum samples were collected before delivery and placenta samples were collected after delivery. Enzyme linked immunosorbent assay was used to detect the level of serum GAS5, real-time PCR was used to detect the level of GAS5 mRNA, SPSS Pearson correlation software was used to analyze the correlation between the incidence of preeclampsia and the level of serum GAS5 and placental GAS5.【Results】The levels of serum GAS5 and placental GAS5 mRNA were 0.185±0.121 and 0.12±0.05 in the observation group, respectively, which were significantly lower than those in the control group (0.332±0.036 and 0.452±0.019, P<0.05). The correlation analysis showed that the levels of serum GAS5 and placental GAS5 mRNA were negatively correlated with the incidence of preeclampsia (r=-0.693,P=0.038;r=-0.712,P=0.027).【Conclusion】 Serum GAS5 and placental GAS5 mRNA in preeclampsia patients show low expression, its expression is negatively related to the pathogenesis of preeclampsia, and may be involved in the occurrence and development of preeclampsia.

Key words： Pre-Eclampsia Placenta

Received: 09 January 2019

PACS:

R714.244

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	Articles by authors
	HU Fei-fei
	XU Xiao-qian
	HUANG Yan

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HU Fei-fei,XU Xiao-qian,HUANG Yan. Expression and Significance of GAS5 in Serum and Placenta of Preeclampsia Patients[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(2): 196-198.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.02.011 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I2/196

[1] 谢玉珍.子痫前期患者血清及胎盘组织中TGF-β_1的表达探讨[J].实用妇产科杂志,2016,32(10):751-755.
[2] 李小叶,唐雅兵.子痫前期孕妇血清以及胎盘组织中ITGB1的表达及临床意义[J].实用医学杂志,2017,33(19):3263-3266.
[3] Rath G, Aggarwal R, Jawanjal P,et al. HIF-1 alpha and placental growth factor in pregnancies complicated with preeclampsia: a qualitative and quantitative analysis[J].J Clin Lab Anal,2016, 30(1):75-83.
[4] 张展,王会平,石瑛,等.IFI16在子痫前期孕妇胎盘组织和血清中的表达及其与子痫前期发病的相关性[J].现代妇产科进展,2017,26(1):11-14.
[5] 米春梅,王丹,高舟.氧化低密度脂蛋白(ox-LDL)、白细胞介素(IL)-22在子痫前期患者血清及胎盘中的表达[J].生殖与避孕,2016,36(7):602-607.
[6] Ben AGM, Bourrelly S, Raguema N,et al.Placental growth factor and vascular endothelial growth factor serum levels in Tunisian Arab women with suspected preeclampsia[J].Cytokine,2016, 79(3):1-6.
[7] 戴薇,许吟,马星卫,等.小剂量低分子肝素联合硫酸镁治疗重度子痫前期对血清和胎盘中病情相关分子的调节作用[J].中国现代医学杂志,2016,26(18):30-33.
[8] 陈娟娟,程澄,谢玉珍,等.维生素C及其转运体SVCT在子痫前期发病机制中的作用研究[J].实用妇产科杂志,2016,32(4):282-285.
[9] 高亚南,张林东,崔世红,等.重度子痫前期胎盘组织中NFAT5表达与围生儿结局的相关性研究[J].现代妇产科进展,2016,25(12):886-890.
[10] 孔红芳,王芳,王凤暖,等.子痫前期患者母血及胎盘组织中HtrA4、Syncytin-1的表达及意义[J].现代妇产科进展,2017,26(1):5-10.
[11] Small HY, Akehurst C, Sharafetdinova L,et al.HLA gene expression is altered in whole blood and placenta from women who later developed preeclampsia[J].Physiol Genomics,2017, 49(3):193.
[12] 卢敏,黄珊萍,郑林媚,等.子痫前期患者血清与胎盘组织中一氧化氮的表达及其意义[J].中国妇幼保健,2016,31(11):2253-2256.
[13] 路艳辉,韩连菊,张蕾,等.子痫前期患者血清和胎盘组织中IL-10和TSP-1的表达及意义[J].河北医药,2016,38(13):2022-2024.
[14] 李春玲,叶龙,陈林,等.血清长链非编码RNACRNDE-h、GAS5检测诊断多发性骨髓瘤的价值分析[J].中国实验诊断学,2016,20(11):1844-1848.
[15] 杨慧, 黄瑞文,张蓉,等. 4例新生儿急性下肢动脉栓塞临床诊疗分析并文献复习[J].医学临床研究, 2018, 35(9):1864-1866.