非酒精性脂肪肝合并2型糖尿病患者的肝脏脂肪含量与各代谢指标的相关性

doi:10.3969/j.issn.1671-7171.2020.02.009

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Abstract 【Objective】To evaluate the application of quantitative measurement of liver fat content (LFC) in patients with nonalcoholic fatty liver disease(NAFLD)complicated with type 2 diabetes mellitus(T2DM)by ultrasound, and to explore the correlation between quantitative results and metabolic indexes.【Methods】A total of 105 patients with NAFLD complicated with T2DM were selected as the observation group, and 43 T2DM patients without fatty liver disease were enrolled as the control group. The FLC was estimated by computer assisted ultrasound. Fully automatic biochemical analyzer detected various metabolic indexes such as serum uric acid (SUA), glutamic acid transaminase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C), blood urea nitrogen (BUN), free fatty acids (FFA), glycated hemoglobin (HbA1C), fasting blood glucose (FPG), fasting insulin (FINS), urine microalbumin (ALB ) and Urine creatinine (CREA). Insulin resistance index was calculated (HOMA-IR = FPG × FINS / 22.5). The differences in metabolic indexes between the two groups were compared and the correlation between LFC and each index was analyzed.【Results】The levels of ALT, TG, LDL-C, FPG, CREA, HOMA-IR, and LFC in the observation group were higher than those in the control group, while the level of HDL-C was lower than that in the control group; the differences were statistically significant (P<0.05). Correlation analysis showed that LFC was positively correlated with ALT and TG in the observation group; and LFC was positively correlated with ALT, AST, and TG in the control group (P<0.05).【Conclusion】 As a common complication of T2DM, NAFLD is used to quantitatively determine LFC by ultrasound. It is simple, low-cost, non-invasive and convenient, and can reflect changes in related indexes such as liver function and lipids. It can be used as a routine screening method for admission and provide a basis for early detection of liver fatty changes.

Key words： Diabetes Mellitus,Type 2/CO Fatty Liver/CO

Received: 15 April 2019

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R587.1

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.02.009 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I2/189

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