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| Relationship between Serum Uric Acid and Homocysteine of Elderly Patients with Heart Failure Preserved by Ejection Fraction |
| ZHANG Hua, WANG Meng, GAO Hua,et al |
| Department of Cardiology, Tangxian People's Hospital, Tangxian, Hebei 072350 |
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Abstract 【Objective】To explore the relationship between the levels of serum uric acid (BUA) and homocysteine (Hcy) and the severity of the disease and prognosis in the elderly patients with heart failure (HFPEF) preserved by ejection fraction.【Methods】A total of 203 elderly HFPEF patients (observation group) admitted to our hospital from March 2016 to September 2017 were divided into two groups according to NYHA cardiac function grade Ⅱ (n=72), cardiac function grade Ⅲ (n=75) and cardiac function grade Ⅳ (n=56). Meanwhile, 50 healthy volunteers in the same period were selected as the control group. BUA, Hcy, NT-proBNP and LVEF were compared in each group. One year follow-up, according to the prognosis, patients were divided into poor prognosis group and good prognosis group. ROC curve was used to analyze the prognostic value of BUA and Hcy. 【Results】The levels of BUA, Hcy and NT-proBNP in the observation group were significantly higher than those in the control group, the difference was statistically significant (P<0.05); compared with levf, the difference was not statistically significant (P>0.05). The levels of BUA, Hcy and NT-proBNP were the highest in grade Ⅳ group, the second in grade Ⅲ group, and the lowest in grade Ⅱ Group (P<0.05). Pearson analysis showed that serum BUA and Hcy levels were positively correlated with NT-proBNP (r=0.784 and 0.732, respectively, P<0.05). 203 patients were hospitalized or died due to adverse mace events (poor prognosis group), including 27 cases of central colic, 19 cases of acute myocardial infarction, 13 cases of serious arrhythmia and 5 cases of death. The other 139 patients were included in the good prognosis group. The proportion of NYHA Ⅲ~Ⅳ, serum BUA, Hcy and NT-proBNP water in patients with good prognosis were lower than those in patients with poor prognosis (P<0.05).【Conclusion】The level of serum BUA and Hcy in HFPEF patients increases significantly, which is positively correlated with left ventricular function, and has a certain reference value for the diagnosis, severity and prognosis of HFPEF.
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Received: 15 January 2019
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2019, Vol. 36 
