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| Correlation between Sleep Structure Abnormalities and Cognitive Function Scores (MMSE and MoCA) in Patients with Alzheimer's Disease |
| LI Huai-su, ZHOU Wen, ZENG Tian-fang,et al |
| Department of Neurology, Second People's Hospital of Chengdu, Sichuan 610017, China |
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Abstract 【Objective】To investigate the relationship between sleep structure abnormalities and cognitive function in patients with Alzheimer's disease. 【Methods】A total of 100 patients with Alzheimer's disease who were treated in our hospital from January 2016 to December 2018 were enrolled, including 50 patients with senile dementia with sleep structural abnormalities (the observation group) and 50 patients with senile dementia without sleep structural abnormalities ( the control group). The changes in sleep parameters were compared between the two groups, and the cognitive function was assessed by using both Montreal Cognitive Assessment Scale (MoCA) and Mini-Mental State Examination (MMSE). The Spearman correlation was used to analyze the correlation between sleep structural abnormalities and cognitive function in patients with Alzheimer's disease. 【Results】There was no significant difference in the proportion of wake-up time, NREM 2 phase, and NREM 1+2 phase between the two groups (P>0.05). Compared to the control group, the proportion of NREM 1 phase and NREM phase in the observation group was significantly increased (P<0.05) and the proportion of the NREM 3+4 phase, REM, MMSE, and MoCA scores were significantly lower (P<0.05) in the observation group. The MMSE score of the observation group was positively correlated with NREM 3+ 4 phase, the nighttime minimum SaO2, and the average SaO2 at night (P<0.05), however, the MMSE score of the observation group was negatively correlated with NREM phase 1 + 2, ODI, AHI (P<0.05). There was no linear correlation of MMSE with REM phase and micro-awakening index (P>0.05). On the other hand, the MoCA score was positively correlated with the nighttime minimum SaO2 and nighttime average SaO2 (P<0.05), and negatively correlated with INREM 1 + 2 phase, oxygen saturation decline index (ODI) and apnea ventilation index (AHI) (P<0.05).The MoCA score was negatively correlated with micro-awakening index and ODI (P<0.05), and positively correlated with the REM phase (P<0.05), and no linearly correlated with the nighttime minimum SaO2 , the average SaO2 at night, the NREM 1 + 2 phase, and the NREM 3 + 4 Phase and AHI (P>0.05). 【Conclusion】Patients with Alzheimer's disease have abnormal sleep structure and decreased cognitive function. There is a correlation between sleep structure changes and cognitive function.
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Received: 13 May 2019
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2019, Vol. 36 
