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| Value of Serum Cys-C , Scr and BNP in Predicting Cardiovascular Events in Chronic Kidney Disease Patients Treated with Maintenance Hemodialysis |
| ZHANG Hong, LI Xiao-wei, SUN Guo-ming |
| Fuyang People's Hospital, Anhui Province 236000 |
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Abstract 【Objective】To investigate the value of serum cystatin C (Cys-C), serum creatinine (Scr) and brain natriuretic peptide (BNP) in predicting cardiovascular events in chronic kidney disease (CDK) patients treated with maintenance hemodialysis (MHD).【Methods】A total of 153 CDK patients who were treated with MHD in our hospital were followed up for 24 months. According to the cardiovascular events at the last follow-up, patients were divided into the cardiovascular event group (group A,n=51) and the non-cardiovascular event group (group B,n=102). Patients' clinical data, blood urea nitrogen (BUN), parathyroid hormone (iPTH), serum Cys-C, Scr and BNP were collected. Regression analysis was performed to identify independent risk factors for cardiovascular events. Receiver operating curve (ROC) was used to analyze the value of Cys-C, Scr and BNP in predicting cardiovascular events.【Results】Patients' age, dialysis time period, serum calcium (Ca), iPTH, uric acid, BUN, Cys-C, Scr and BNP in group A were significantly higher than those in group B (P<0.05). Cys-C, Scr and BNP were positively correlated with dialysis time period, serum Ca, iPTH, uric acid and BUN (P<0.05). Multivariate logistic stepwise regression analysis showed that iPTH, uric acid, Cys-C, Scr and BNP were independent risk factors for cardiovascular events in MHD patients (P<0.05). The areas under ROC curve of Cys-C, Scr and BNP in predicting cardiovascular events were 0.705, 0.614 and 0.739, respectively. The sensitivity was 79.2% for Cyc-C, 71.4% for Scr and 84.3% for BNP;And the specificity was 73.5%,67.3% and 86.5%, respectively.【Conclusion】Cys-C, Scr and BNP are independent risk factors for cardiovascular events in CDK patients with MHD and can predict the occurrence of cardiovascular events.
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Received: 29 September 2018
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2019, Vol. 36 
