AbstractObjective This aim was to investigate the relationship between cognitive function and serum levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), homocysteine (Hcy) and Cys C in patients with senile dementia (Alzheimer's disease). Methods A total of 106 patients with senile dementia admitted to our hospital from June 2014 to October 2017 were selected in the study. According to MMSE score, patients were divided into two groups: Alzheimer's disease (AD,n=59) and mild cognitive impairment (MCI, n=47). Meanwhile, 40 healthy subjects with matched health and education status in the same period were selected as the control group. Logistic regression analysis was used to analyze the relationship between the risk of dementia and serum indexes. Results The levels of Hcy and hs-CRP were AD group > MCI group > the control group (P<0.05). Cys C level order was AD group < MCI group < the control group (P<0.05). The level of IL-6 seemed to show AD group > MCI group > the control group. However, the differences were not statistically significant (P<0.05). The serum levels of IL-6, hs-CRP, Hcy and Cys C in AD patients were not significantly correlated with MMSE scores (P>0.05). The prevalence of AD is associated with levels of low folate, high hs-CRP and high Hcy. Conclusion The results show that there is no significant correlation between cognitive function and serum levels of IL-6, hs-CRP, Hcy and Cys C in patients with Alzheimer's disease. Low folate, high Hcy levels and high hs-CRP levels may increase the risk of AD by some mechanism. Cys C may be protective factors of cognitive impairment in AD.
GUO Min,JIN Di,WANG Pei-fu, et al. Analysis of Correlation between Cognitive Function and Levels of IL-6, hs-CRP, Hcy and Cys C in Patients with Senile Dementia[J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(2): 284-284.
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