结肠癌相关因素和DNA甲基转移酶1基因多态性与结肠癌易感性的相关性分析

doi:10.3969/j.issn.1671-7171.2018.09.020

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Abstract 【Objective】 To investigate the interaction of DNA methyltransferase 1 (DNMT1) gene polymorphism with colon cancer susceptibility related factors. 【Methods】 A total of 110 patients with colon cancer treated in Department of Oncology of our hospital from February 2013 to December 2017 were selected as the observation group, and 50 healthy volunteers in the same time period were selected as the control group. A self-made questionnaire on epidemiology of colon cancer was used to investigate the basic information, history of previous digestive tract diseases and dietary habits. The polymorphism of s16999593 was detected by fluorescence quantitative PCR. The differences of genetic polymorphisms and related factors in two groups, as well as correlation with colon cancer susceptibility were analyzed. 【Results】 In the observation group and the control group, there were significant differences in the aspects of intestinal polyps, colitis, cholecystitis, drinking, intake of fresh fruits and vegetables, and intake of pickled, spicy and greasy foods (P<0.05). Individuals carrying at least one C allele (CT+CC) were 2.250 times more likely to develop colon cancer than individuals with wild homozygous TT genotypes (95% CI 1.105 to 4.581, P=0.024). Polymorphism of s16999593 was positively correlated with intestinal polyps, colitis, cholecystitis, drinking, less intake of fresh fruits and vegetables, and more intake of pickled, spicy and greasy foods (P＜0.05). 【Conclusion】 Individuals carrying at least one C allele of the s16999593 locus have an increased risk of colon cancer. S16999593 polymorphism is positively correlated with intestinal polyps, colitis, cholecystitis, drinking, and frequent intake of pickled, spicy, greasy foods, which increases the risk of colon cancer. It is negatively correlated with more intake of fresh fruits and vegetables, which reduces the risk of colon cancer.

Key words： Colonic Neoplasms/ET Genes

Received: 17 July 2018

PACS:

R735.35

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Cite this article:

TU Hai-ming. Correlation of DNA Methyltransferase 1 Gene Polymorphism with Colon Cancer Susceptibility Related Factors[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(9): 1727-1729.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.09.020 OR http://www.jcr.net.cn/EN/Y2018/V35/I9/1727

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