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| Predictive Value of Serum PCT and CRP Levels for Anastomotic Leakage of Rectal Cancer after Laparoscopic Total Mesenteric Resection |
| HOU Lei, LV Xiao-feng, ZHAO En-hong |
| Gastrointestinal Surgery,Affiliated Hospital of Chengde Medical College, Chengde, Hebei, 067000, China |
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Abstract 【Objective】 To investigate the value of combined detection of serum PCT (procalcitonin) and CRP (C-reactive protein) in predicting anastomotic leakage of rectal cancer after laparoscopic total mesenteric resection. 【Methods】 The clinical data of 328 patients with rectal cancer who underwent laparoscopic total mesenteric resection in our hospital from April 2013 to March 2017 were analyzed retrospectively. Patients were divided into anastomotic leakage group (n=28) and non-anastomotic leakage (n=300) according to the occurrence of anastomotic leakage. The levels of serum procalcitonin (PCT) and C-reactive protein (CRP) at 1 day, 3 days, and 5 days after surgery were compared between the two groups. The ROC curves of anastomotic leakage predicted by PCT and CRP at different time points were drawn, and the sensitivity and specificity of PCT combined with CRP for predicting anastomotic leakage were evaluated. 【Results】 The serum level of PCT in the anastomotic leakage group was higher than that of the non-anastomotic leakage group at 1 d, 3 d, and 5 d after operation (P<0.05). There were no significant differences in serum CRP levels between the two groups at 1 and 3 days after surgery (P>0.05). However, the serum level of CRP was higher in the anastomotic leakage group than in the non-anastomotic leakage group at 5 days after operation (P<0.05). Serum levels of PCT at 1 day, 3 days, 5 days after operation and level of CRP at 5 days after operation had significantly predictive value for anastomotic leakage . The critical values were 130.50 pg/ml and 111.50 pg/ml, 96.25 pg/ml, and 37.00 mg/L, respectively.. The sensitivity of PCT combined with CRP for predicting anastomotic leakage was 95.83% and specificity was 75%.【Conclusion】 Postoperative detection of serum PCT and CRP has great predictive value for the occurrence of anastomotic leakage after laparoscopic rectal cancer total mesenteric resection. The combined detection of PCT and CRP can obtain higher sensitivity and specificity.
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Received: 02 August 2018
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2018, Vol. 35 
