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| Efficacy of GnRHa Combined Kuntai Capsule on Endometriosis |
| XIEShan-li |
| First People's Hospital of Guangyuan, Sichuan Province ,Guangyuan 628017 |
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Abstract 【Objective】 To evaluate the effect of gonadotropin releasing hormone agonist (GnRHa) combined with kuntai capsule on the sex hormone and humoral immunity of endometriosis patients. 【Methods】 A total of 150 patients with endometriosis in our hospital from April 2015 to February 2017 were selected and randomly divided into two groups: the control group (75 cases) and the observation group (75 cases). The control group was treated with GnRHa, and the observation group was treated with Kuntai capsule on the basis of the control group. The changes of sex hormones, humoral immunity index, Kupperman score and bone mineral density before and after treatment were compared between the two groups, and the clinical efficacy and medication safety of the two groups were evaluated.【Results】 The total effective rate of the observation group was 90.67% (68/75), which was significantly higher than that of the control group 70.67% (53/75). The adverse reaction rate of the observation group was 5.33% (4/75),which was lower than that of the control group of 16.00% (12/75). The difference was statistically significant (P<0.05). After treatment, the levels of serum estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), complement 3 and 4 (C3 and C4) in the observation group were lower than those in the control group; the difference were statistically significant (P<0.05). There were no statistically significant differences in serum immunoglobulin G (IgG), IgM and bone density between the two groups before and after treatment (P>0.05). After treatment, the C4 levels and complement were lower than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the Kupperman score in the observation group was lower than that in the control group; and the differences were statistically significant (P<0.05). 【Conclusion】 The treatment of GnRHa combined Kuntai capsule for endometriosis patients has better curative effect. It can adjust body sex hormone levels, improve humoral immune function, and alleviate or eliminate clinical symptoms with medication safety.
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Received: 24 October 2017
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2018, Vol. 35 
