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| Effect of Analgesia Mode in Childbirth on Stress status, Immune Function and Pregnancy Outcome |
| JIANGRong, YANGMong-chang, LIPeng |
| Department of Anesthesiology, The people's Hospital of ShiChuan, Chengdu, Sichuan 610072 |
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Abstract 【Objective】 To analyze the effect of analgesia mode during childbirth on stress status, immune function and pregnancy outcome. 【Methods】 A total of 164 pregnant women were randomly divided into two group according to the different ways of labor analgesia. The control group was given the analgesic measures of epidural delivery, and the observation group was given a combination of lumbar and hard epidural anesthesia for labor analgesia. The analgesic effect, postpartum stress, immune function before and after delivery and pregnancy outcome were compared and analyzed in the two groups. 【Results】 The total analgesic rate of the observation group was 87.80% (72/82), which was significantly higher than that of the control group, which was 69.51% (57/82) (P<0.05). The anxiety self-rating scale (SAS) score and depression self-rating scale (SDS) score of the observation group were all lower than those of the control group, which showed the incidence of anxiety and depression were lower than those of the control group (P<0.05). There was no significant difference in the level of immune function between the two groups (P>0.05). After delivery, levels of CD4+, CD8+, and CD4+/CD8+ in the two groups decreased, while IL-6 increased (P<0.05). The levels of CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group, however, the levels of CD8+ and IL-6 were lower than those in control group (P<0.05). The cesarean section rate in the observation group was 6.10%, which was significantly lower than that in the control group (20.73%) (P<0.05). The incidence of total adverse reactions in the observation group was significantly lower than the control group (P<0.05). 【Conclusion】 Combined spinal epidural anesthesia for labor analgesia can significantly improve the analgesic effect, improve postpartum stress and immune function, and improve safety.
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Received: 11 April 2018
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2018, Vol. 35 
