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| The Clinical Study of Ibandronate Administration in the Treatment of Metastatic Bone Pain in the Patients of Malignant Cancer |
| YANGLu-lu, DENGWeng-ying, LUOSu-xia |
| Department of Digestive Medicine,the Cancer Hospital Affiliated to Zhengzhou University, Zhengzhou 450008, Henan Province |
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Abstract 【Objective】 To observe the curative effect and safety of the first dose loading and the repeated loading dose of ibandronate in the treatment of metastatic bone pain of malignant tumors. 【Methods】 Forty patients with malignant bone metastases from 2012 to 2017 were selected, including 20 cases in the first dose loading group (group A) and 20 cases in the repetitive loading dose group (group B). The pain score, quality of life KPS score, onset time of analgesia, duration of analgesia maintenance, and adverse reactions were observed and recorded before and after the application of ibandronate. 【Results】 The effective rate of pain relief was 55% (11/20) in the group A and 90% (18/20) in the group B (P<0.05). The scores of quality of life (QOL) in the group A (83±10.89) were lower than those in the group B (91.00±7.88), and the difference was significant (P<0.05). The time of analgesic effect and maintenance were (3.60 ±0.50) days and (20.35 ±1.87) days in the group A, lower than those in the group B (2.70±0.40) days and (23.30±1.34) days, respectively (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 Repeated administration of ibandronate has a good analgesic effect and could improve metastatic bony pain rapidly, the kidney of the patients has good tolerance and mild adverse reaction, which is worth popularizing.
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Received: 22 May 2018
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2018, Vol. 35 
