微创介入治疗肝癌对患者T细胞免疫功能的影响

doi:10.3969/j.issn.1671-7171.2018.07.018

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Abstract 【Objective】To study the clinical effect of minimally invasive interventional therapy on hepatocellular carcinoma and its influence on T cell immune function in patients.【Methods】A total of 40 liver cancer patients who treated by transcatheter arterial chemoembolization and 40 patients with liver cancer who treated by radiofrequency ablation in our hospital between January 2014 and December 2017 were categorized group A and group B, respectively. The clinical data of the two groups were analyzed retrospectively, and the clinical efficacy, T cell immune function index, postoperative complications, liver function index, postoperative pain score and quality of life score were compared between the two groups.【Results】In terms of clinical efficacy, there was no significant difference in objective remission rate and total effective rate between the two groups( P > 0.05). Compared to that in group A, the serum ALT level in group B was significantly higher ( P < 0.05). After operation, the CD3⁺ and CD4/CD8 of the two groups were lower than those before the operation( P < 0.05), while the CD3⁺ and CD4/CD8 in group B were higher than those in the group A ( P < 0.05). There was no significant difference in the incidence of postoperative complications between the two groups ( P > 0.05). The scores at 8h, 12h, 24h and 48h after operation in group B were lower than those in group A ( P < 0.05). After operation, the quality of life scores in both groups were significantly higher than those before the operation ( P < 0.05), but that in group B was higher than that in group A ( P < 0.05).【Conclusion】The use of radiofrequency ablation in the treatment of liver cancer patients can reduce the interference of interventional therapy on the immune function of T cells and liver function as much as possible on the premise of interventional therapy, which is beneficial to alleviating postoperative pain and improving the quality of life.

Key words： Liver Neoplasms Catheter Ablation T-Lymphocytes Immunoassay

Received: 05 June 2018

PACS:

R735.7

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	YI Ze-jun
	WU Jian-ping

Cite this article:

YI Ze-jun,WU Jian-ping. Changes of T Cell Immune Function in Patients with Liver Cancer Treated by Minimally Invasive Interventional Therap[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(7): 1301-1303.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.07.018 OR http://www.jcr.net.cn/EN/Y2018/V35/I7/1301

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