Abstract 【Objective】 To investigate the effect of negative pressure and recombinant human growth hormone on senile diabetic foot. 【Methods】One hundred and two senile diabetic foot patients were randomly divided into observation group and control group with 51 cases in each group. The patients in the control group were treated with negative pressure drainage, and the patients in the observation group were treated with recombinant human growth hormone on the basis of the control group. The curative effect, wound healing, hospital stay, pain improvement and serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were compared between the two groups before and after treatment. 【Results】 The total effective rate of treatment in the observation group was 94.12, which was significantly higher than that in the control group (76.47%), and the difference was statistically significant ( P < 0.05). The granulation tissue thickness and wound healing time in the observation group were better than those in the control group ( P < 0.05). The time of hospitalization in the observation group was shorter than that in the control group ( P < 0.05). The levels of serum IGF-1 and IGFBP-3 in the control group were not significantly changed before and after treatment ( P > 0.05), and the levels of serum IGF-1 and IGFBP-3 in the observation group increased after treatment ( P < 0.05) and were higher than those in the control group ( P < 0.05). 【Conclusion】 Negative pressure of wound combined with recombinant human growth hormone is effective in treating senile diabetic foot patients. It can promote wound healing and increase serum IGF-1 and IGFBP-3 levels, which is worthy of clinical application.
2018, Vol. 35 
