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| Effects of Different Anesthetic Depths on Stress Injury, Circulatory System and Postoperative Cognitive Function in Children under General Anesthesia |
| OU Ming-ling |
| Department of Anesthesiology, the Chengdu Central Hospital for Women and Children ,Chengdu, Sichuan, 610000 |
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Abstract 【Objective】 To investigate the effect of different depths of anesthesia under bispectral index (BIS) monitoring on stress response, circulatory system and postoperative cognitive function in children receiving general anesthesia. 【Method】 One hundred and fifty cases of children undergoing elective operation under total intravenous anesthesia were divided into group A and group B. The BIS value in the group A was maintained at 40~50 while that in the group B was maintained at < 50~60. The hemodynamic indexes, stress reaction indexes ,MMSE and anaenf esthesia effect at different time points were compared between the two groups. 【Results】At time of completing operation(T3) and 1 day after operation(T5), there was no significant difference in heart rate (HR) and mean arterial pressure (MAP) between the two groups ( P > 0.05). The levels of plasma endothelin-1 (ET-1) and adrenocorticotropic hormone (ACTH), C-reactive protein (CRP) in the group A were significantly lower than those in the group B ( P < 0.05). The scores of MMSE at 24 hours after operation in both groups were significantly lower than those at 1 hour before operation ( P < 0.05), but there was no significant difference in MMSE scores between the two groups at different time points ( P > 0.05), and no significant adverse reactions occurred in both groups.【Conclusion】The hemodynamic stability of children with general intravenous anesthesia is effectively maintained under different anesthetic depths monitored by BIS. The effects of different anesthetic depths on cognitive function of children are similar, but the effect of BIS 40~50 on stress response is less than that of < 50~60.
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Received: 22 May 2017
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[1] An JX, Fang QW, Huang CS, et al .Deeper total intravenous anesthesia reduced the incidence of early postoperative cognitive dysfunction after microvascular decompression for facial spasm[J]. J Neurosurg Anesthesiol, 2011, 23(1): 12-17.
[2] 许惠娟,彭清雄,潘道波,等.不同麻醉深度对硬膜外联合全身麻醉老年患者下腹部手术早期术后认知功能障碍的影响[J].医学临床研究,2016,33(4):680-682,685.
[3] 黄俊祥,宋兴荣,田航,等.Narcotrend麻醉深度监测在小儿全身静脉麻醉中的应用[J].中华妇幼临床医学杂志(电子版),2014,10(4):507-510.
[4] 朱联周,于湘友,马玉华,等.老年患者胃癌根治术丙泊酚靶控浓度与脑电双频指数变化的关系[J].湖南师范大学学报(医学版),2015,12(1):42-45.
[5] 时玥,王洪南,马虹,等.不同麻醉深度对全身麻醉患者关节置换术后早期认知功能的影响[J].山西医药杂志,2013,42(5):261-263.
[6] 黎达锋,曾秋谷,梁华娜,等.Narcotrend脑电监测不同麻醉深度对全麻患者POCD发生和S100β蛋白水平影响的临床分析[J].医学综述,2014,20(15):2851-2853.
[7] Hudetz JA,Gandhi SD,Iqbal Z, et al .Elevated postoperative inflammatory biomarkers are associated with short-and medium-term cognitive dysfunction after coronary artery surgery[J]. J Anesth, 2011,25(1):1-9. |
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2018, Vol. 35 
