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| Effect of Compound Kushen Injection Combined with Radiotherapy and Chemotherapy on Cervical Cancer |
| CAI Tao, SUN Lan-Zheng, WANG Ting, et al |
| Department of pharmacy, No. 82 Hospital of PLA, Huaian, Jiangsu.223001 |
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Abstract 【Objective】To evaluate the effect of compound Kushen injection combined with radiotherapy and chemotherapy on cervical cancer. 【Methods】The clinical data of 105 patients with cervical cancer who were treated in our hospital from June 2015 to January 2017 were collected. According to different treatment regimens, patients were divided into the single-use group and the combined group. The single-use group consisted of 52 cases who were given concurrent radiotherapy and chemotherapy, while the combined group of 53 cases received the compound Kushen injection plus chemoradiotherapy. T lymphocyte subsets, natural killer cells (NK) and serum tumor antigens [insulin-like growth factor-2 (IGF-2), squamous cell carcinoma-associated antigens were observed before and after treatment for 3 courses. SCC and cytokeratin 19 fragment antigen (CYFRA21-1)] were measured before treatment and after 3 courses of treatment. The therapeutic efficacy and safety between the two groups were evaluated and compared. 【Results】The total effective rate of the combined group was 52.83% (28/53), which was significantly higher than that of the single-use group, which was 32.69% (17/52). The incidence of adverse reactions was 47.17% (25/53) in the combined group, which was lower than in the single-use group, which was 75.00% (39/52). The difference was statistically significant ( P < 0.05). The levels of CD3+, CD4+, CD4+/CD8+ and NK in the combined group were higher than those in the single-use group, and the differences were statistically significant ( P < 0.05). The CD8+ level in the combined group was lower than that in the single-use group ( P < 0.05). After treatment, the levels of IGF-2, SCC and CYFRA21-1 in the combined group were lower than those in the single-use group ( P < 0.05). 【Conclusion】The application of Kushen injection combined with radiotherapy and chemotherapy in patients with cervical cancer is effective in promoting the enhancement of cellular immune function, reducing the level of tumor antigen and reducing the occurrence of adverse reaction.
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Received: 05 May 2017
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[1] 王武峰,彭少华,李有强. 调强放疗与三维适形放疗治疗宫颈癌疗效比较[J]. 医学临床研究,2017,34(9):1797-1799.
[2] 高晓兰. 顺铂新辅助化疗联合扶正驱邪中药治疗晚期宫颈癌的临床疗效研究[J].中国妇幼保健,2014,29(5):691-693.
[3] 中国抗癌协会.新编常见恶性肿瘤诊治规范[M].北京:中国协和医科大学出版社,1999: 774-786.
[4] 张萍,艾斌.实体瘤免疫治疗疗效评价标准[J].国际肿瘤学杂志,2016,43(11):848-851.
[5] 徐西伟,黄晓萍,刘巧丹,等.Ⅰb2-Ⅱa期巨块型宫颈癌热疗联合同步放化疗与同步放化疗的疗效比较[J].中山大学学报(医学科学版),2016,37(5):751-756.
[6] 崔桐,韩存芝.血清鳞状细胞癌抗原和癌胚抗原联合检测对子宫颈癌的诊断及疗效评价[J].肿瘤研究与临床,2016,28(08):513-518.
[7] 张玉. 人乳头瘤病毒E6/E7蛋白在子宫颈癌中的研究进展[J].肿瘤研究与临床,2016,28(8):573-576.
[8] 陈仲波,余红萍,朱笕青,等.合并HPV 感染宫颈癌患者外周血 Th1/Th2细胞免疫功能变化及临床意义[J].中华医院感染学杂志,2016,26(24):5677-5679.
[9] 侯超男,张蔚.苦参碱对宫颈癌Hela细胞增殖及其相关蛋白影响[J].临床和实验医学杂志,2016,15(18):1803-1806.
[10] 张慧君,薛敬礼,刘红春,等.苦参素对实验性自身免疫性脑脊髓炎大鼠脑内神经干细胞增值的影响[J].中风与神经疾病杂志,2016,33(12):1101-1103. |
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2018, Vol. 35 
