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| Effect of Tripterygium Wilfordii Multi Glucoside Tablets on the Treatment of Elderly IgA Nephropathy and Its Effect on PAI-1 and TGF- beta 1 |
| DANG Tong-guang, HAN Chao, WANG Cui, et al |
| Department of Urology,People's Central Hospital of Tengzhou, Shandong Province 277500 |
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Abstract 【Objective】 To study the effects of Tripterygium wilfordii multi glucoside tablets on the treatment of elderly IgA nephropathy and its effects on plasminogen activator inhibitor type-1 (PAI-1),Transforming growth factor beta 1 (TGF-β1). 【Methods】According to lottery drawing method, 90 elderly patients of IgA nephropathy were divided into two group, with 45 cases in each. Patients in the control group received routine treatment, while patients in the observation group were treated with glycosides of Tripterygium wilfordii (20mg each time with 3 times a day) in addition to routine treatment of the control group. The two groups were treated for one year. Afterwards, the therapeutic efficacy-levels of urinary protein, SCr (serum creatinine), Alb (plasma albumin) BUN (serum urea nitrogen), PAI-1, and TGF- beta 1-were compared between the two groups. 【Results】 The total effective rate of the observation group was significantly higher than that of the control group(P＜0.05). The levels of urine protein content, SCr, BUN, PAI-1 and TGF- beta 1 in the observation group were significantly lower than those in the control group(P＜0.05). The level of Alb of the observation group was significantly higher than that of the control group(P＜0.05); There was no significant difference in adverse reactions between the two groups (P>0.05). 【Conclusion】Glycosides of Tripterygium wilfordii is effective for treatment of elderly IgA nephropathy. It can improve renal function, reduce urinary protein, delay disease progression and decrease the expression of PAI-1 and TGF- beta 1.
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Received: 27 December 2017
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2018, Vol. 35 
