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| Value of MicroRNA-499 on the Diagnostic and Prognosis in Patients with ST-elevation Myocardial Infarction |
| HAN Song, WANG Qing-hai, CHEN Shi-jin |
| Department of Cardiology,The Second People's Hospital of Yichang,Yichang, Hubei,443000 |
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Abstract 【Objective】To detect the value of microRNA-499 on the diagnostic and prognosis in patients with ST-elevation myocardial infarction.【Methods】From January 2014 to March 2016, 74 STEMI patients admitted to our hospital from January 2014 to March 2016 were selected as clinical data (observation group) and 80 healthy volunteers as control group. In all subjects, venous blood was taken immediately after admission for the detection of miR-499 concentrations. All patients were followed up for 6 months to record major adverse cardiovascular events (Mace). By Persean correlation analysis, the linear relationship between miR-499 and CK-MB and cTnI was studied, and the difference of miR-499 concentration between STEMI patients with Mace and those without Mace was compared.【Results】 The level of miR-499 in peripheral blood circulation in STEMI patients was significantly higher than that in healthy controls (P<0.01). The level of circulating miR-499 was positively correlated with troponin I (cTnI) (r=0.475,P<0.01) and CK-MB (r=0.526,P<0.01). 31 STEMI patients were classified as Mace group, while the remaining STEMI patients were not classified as non-MACE group. It was found that the concentration of miR-499 in peripheral blood circulation in Mace group was significantly higher than that in non-MACE group (P<0.01). 【Conclusion】Circulating miR-499 can be used as a potential marker for the diagnosis of STEMI and the evaluation of its clinical prognosis.
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Received: 29 March 2018
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2018, Vol. 35 
