下呼吸道细菌定植对老年COPD稳定期患者预后与转归的影响

doi:10.3969/j.issn.1671-7171.2018.06.012

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Abstract 【Objective】To investigate the effect of low airway bacterial colonization (LABC) on the outcomes and prognosis of senile patients with chronic obstructive pulmonary disease (COPD) at stable stage, and to provide reference for assessing the severity of disease and treatment. 【Methods】A total of 85 elderly patients with stable COPD from May 2016 to August 2017 were selected as the study subjects and quantitative bacterial cultures were performed on their induced sputum. According to whether or not LABC occurred, they were divided into colonization group (53 cases) and non-colonization group (32 cases). The levels of serum inflammatory factors, symptoms, and lung function grading were compared between the two groups. 【Results】A total of 83 elderly patients with stable COPD contained 53 cases of LABC; the incidence rate was 62.35%. The main bacteria were haemophilus influenzae (30.19%), Streptococcus pneumoniae (16.98%) and Moraxella catarrhalis (13.21%). The proportion of colonizing strains and the amount of colonization were positively correlated. The levels of serum interleukin-8 (IL-8), high-sensitivity C-reactive protein (hs-CRP), the average number of acute exacerbations per year, and the rate of combined lower respiratory tract infection were higher in the colonization group than in the non-colonization group (t/χ²=9.615, 7.487, 5.817, 13.833,P<0.05, P<0.01). The extremely severe rate of lung function classification was 18.87%, significantly higher than that of the non-colonization group (3.13%) (χ²=4.389,P<0.05). 【Conclusion】The incidence of low airway bacterial colonization of elderly patients with COPD at the stable stage is high. Bacterial colonization can aggravate the airway inflammatory reaction, increase the incidence of acute attacks and lower respiratory infection, reduce lung function, and seriously affect the outcomes and prognosis of patients.

Key words： BacterialInfections/CO PulmonaryDisease,ChronicObstructive/CO Aged

Received: 10 May 2018

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R563.1

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	LI You-jun
	MAO Jian-chuan

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LI You-jun,MAO Jian-chuan. Effect of Low Airway Bacterial Colonization on the Outcomes and Prognosis of Elderly COPD Patients at Stable Stage[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(6): 1076-1078.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.06.012 OR http://www.jcr.net.cn/EN/Y2018/V35/I6/1076

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