新筛高TSH血症患儿甲状腺功能恢复情况与生长发育状况的关系分析

doi:10.3969/j.issn.1671-7171.2018.06.003

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Abstract 【Objective】To explore the relationship between the recovery of thyroid function and the growth and development of children with newly screened TSH (thyroid stimulating hormone) hyperthyroidemia, and to provide references for the formulation of therapeutic indications and treatment goals. 【Methods】 A total of 281 children with newly screened high TSH hyperthyroidemia who were admitted to our hospital from February 2014 to February 2017, according to the recovery of thyroid function during follow-up , were divided into the TSH natural recovery group and the drug treatment group. In the same time period, 60 healthy children of similar age were selected as the control group. We compared the intelligence and growth development of the three groups at the age of one year, and analyzed the effects of serum TSH on children's growth and development.【Results】Of the 281 cases of high TSH hyperthyroidemia patients, 237 cases (84.34%) showed their TSH returned to normal level naturally (without any treatment) during the follow-up period, of which 176 cases returned to normal within 3 months, 55 cases return to normal within 3~6 months, and 6 cases returned to normal within 6~9 months. The remaining 44 patients with high serum TSH more than 15 mIU/mL during the initial or follow-up period received levothyroxine sodium tablets. Of these, 35 cases returned to normal serum TSH level after treatment. However, the remaining 9 patients still maintained at high TSH hyperthyroidemia even after receiving the treatment. There were no significant differences between the MDI (mental development index) and PDI (psychological development index) scores of the three groups of children at the age of one year (P>0.05). The children's height of the three groups at the age of one year did not show significant difference (P>0.05).【Conclusion】The thyroid function of most children with newly screened high serum TSH hyperthyroidemia can return to normal in a short time, and high TSH hyperemia does not have a significant influence on the growth and development of children.Clinical treatment indications should be carefully judged to avoid overtreatment.

Key words： Hyperpituitarism/DT ThyroidDiseases/CL RecoveryofFunction ChildDevelopment

Received: 03 April 2018

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R581

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.06.003 OR http://www.jcr.net.cn/EN/Y2018/V35/I6/1047

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