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| Clinical Value of Combined Detection of HE4, CA125, B7-H4, B7-H6 and Foxp3 in Ovarian Cancer |
| ZHAO Wei, ZHENG Feng-jun, YAO Xiu-ling |
| Obstetrics and Gynecology,the Second People 's Hospital ,Hengshui City, Hebei Province 053000 |
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Abstract 【Objective】To investigate the clinical value of combined detection of serum human epididymal protein 4 (HE4), ovarian cancer carbohydrate antigen 125 (CA125), B7-H4, B7-H6 and peripheral blood Foxp3+Treg in ovarian cancer Value. 【Methods】From February 2012 to February 2017, 105 patients with ovarian cancer diagnosed by pathology in Obstetrics and Gynecology of the Second People's Hospital of Hengshui City were selected as observation group and 105 as benign ovarian tumors as control group. All patients underwent HE4, CA125, B7-H4, B7-H6 detection and peripheral blood Foxp3+ Treg levels. 【Results】The serum levels of HE4, CA125, B7-H4, B7-H6 and peripheral blood Foxp3+ Treg in the observation group were significantly higher than those in the control group (P<0.05). The sensitivity, specificity, positive predictive value and negative predictive value of combined detection were better than single detection results of serum HE4, CA125, B7-H4, B7-H6 and peripheral blood Foxp3+ Treg, the difference was statistically significant (P<0.05) . 【Conclusion】The combined detection of serum HE4, CA125, B7-H4, B7-H6 a nd peripheral blood Foxp3+ Treg has higher sensitivity, specificity, positive predictive value and negative predictive value, which can help to improve the diagnosis rate of ovarian cancer.
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Received: 26 March 2018
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[1] 石华, 罗蔚, 李文胜, 等. 血清人附睾上皮分泌蛋白4水平检测在卵巢癌的应用价值[J].实用妇产科杂志, 2015, 31(4):267-270.
[2] 王珂, 汪丽, 程苏晶, 等. 血清 CA125 和 CA199 检测对卵巢癌诊断应用价值的探讨[J].中国实验诊断学, 2014, 18(4):574-576.
[3] 张亮, 孟杰. 超声联合血清肿瘤标记物 CA125, B7 同源体 4 (B7-H4) 对卵巢癌的诊断价值[J].实用癌症杂志, 2017, 32(8):1364-1366.
[4] 周怡, 陈陆俊, 徐云, 等. 协同刺激分子 B7-H6 在卵巢癌中的表达及其临床意义[J].现代免疫学, 2015, 35(5):353-357.
[5] 侯娟娟, 虎淑妍, 刘婷婷,等.血清肿瘤标志物在卵巢癌早期诊断中的临床价值[J].中国免疫学杂志, 2014, 30(8):1101-1104.
[6] 马丽. 上皮性卵巢癌患者血清人附睾蛋白4, 糖类抗原125水平的检测及意义分析[J].中国医学工程, 2017, 25(1):54-56.
[7] 李静, 彭曦, 江静,等.卵巢癌患者不同方案化疗前后 HE4 和 CA125 变化情况分析[J].中国医院药学杂志, 2017, 37(12):1171-1173.
[8] 李晓贻, 时燕萍, 夏亲华. FOXP3, B7-H4 在卵巢子宫内膜异位囊肿组织中的表达及意义[J].山东医药, 2017, 57(14):89-91.
[9] 万静华, 傅振坤. 抑制性协同刺激分子 B7-H4 在女性常见恶性肿瘤中的研究进展[J].实用肿瘤学杂志, 2015, 29(1):53-56.
[10] 朱京津, 穆春华, 闫洪超. 血清肿瘤标记物 CA125, B7-H4 联合超声检查在卵巢癌诊断中的价值[J].山东医药, 2014, 54(48):34-35.
[11] 陈颖, 何杨, 莫骏. B7 家族成员 B7-H6 在肿瘤免疫中的研究进展[J].中华微生物学和免疫学杂志, 2015, 35(012):932-934.
[12] 张淑平, 吴梦, 柯星, 等. 卵巢癌细胞生长微环境诱导生成的 CD8+ Treg 的表型及功能[J].实用医学杂志, 2016, 32(12):1926-1929.
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(8): 1648-1650. |
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2018, Vol. 35 
