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| Correlation Analysis of Insulin Pump Base Amount and BMI,HbA1c in Patients with Newly Diagnosed Type 2 Diabetes |
| HUANG Guo-sheng, ZHANG Jin-ming, ZHAO Lin, et al |
| Department of Cardiovascular, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510145, China |
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Abstract 【Objective】To investigate the correlation between the basic amount of initial intensive insulin pump therapy and body mass index (BMI), glycosylated hemoglobin (HbA1c) in patients with newly diagnosed type 2 diabetes mellitus (T2DM).【Methods】From January 2015 to June 2017, 93 newly diagnosed T2DM patients in Department of Endocrinology, Guangdong Provincial Hospital of traditional Chinese Medicine, receiving intensive insulin pump therapy, were selected, and the general data of the patients were collected. BMI and WHR were calculated. Serum biochemical indexes were detected by automatic biochemical analyzer, whole blood HbA1c was measured by HPLC, fasting blood glucose (FBG) and 2 h postprandial blood glucose (2hPGG) were monitored during treatment. The correlation between the basic quantity of insulin pump and clinical index was analyzed.【Results】After intensive treatment with insulin pump, 72 patients reached the standard of blood glucose and 21 patients failed to reach the standard. The BMIs, the total amount of insulin pump and the basic quantity of insulin pump were significantly lower than those in the substandard group (P<0.05). There was a positive correlation between the basal insulin pump level and the course of BMI, FPG, 2hPG and HDL-C (mean P<0.05), and a negative correlation with low density lipoprotein cholesterol (LDL-C) (P<0.05), and no correlation with age, WHR, HbA1c, TC, TGs (mean P>0.05).【Conclusion】For patients newly diagnosed with type 2 diabetes, BMI is associated with the basal volume of initial insulin pump therapy and can be used as a reference indicator of basal insulin pump volume.
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Received: 05 July 2017
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[1] Lou M,Peng L,Ru T,et al.Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients[J].BMC Endocr Disord,2015,15(1):9.
[2] Li R,Xu W,Luo S,et al.Effect of exenatide,insulin and pioglitazone on bone metabolism in patients with newly diagnosed type 2 diabetes [J].Acta Diabetol,2015,52(6):1083-1091.
[3] Tian M,Liang Z,Liu R,et al.Effects of sitagliptin on circulating zinc-α2-Glycoprotein levels in newly diagnosed type 2 diabetes patients:a randomized trial [J].Eur J Endocrinol,2016,174(2):147-155.
[4] Bala M,Meenakshi,KM,et al.Correlation of hba1c levels with body mass index in newly diagnosed polycystic ovary syndrome[J].EJIFCC,2017,28(3):196.
[5] Cheng Q,Yang S,Zhao C,et al.Efficacy of metformin-based oral antidiabetic drugs is not inferior to insulin glargine in newly diagnosed type 2 diabetic patients with severe hyperglycemia after short-term intensive insulin therapy[J].J Diabetes,2015,7(2):182-191.
[6] Sumitani S,Morita S,Deguchi R,et al.Metformin decreases glycated albumin to glycated haemoglobin ratio in patients with newly diagnosed type 2 diabetes[J].Ann Clin Biochem,2015,52(Pt 1):76.
[7] Li Q,Zeng H,Liu F,et al.High Ankle-Brachial Index Indicates Cardiovascular and Peripheral Arterial Disease in Patients With Type 2 Diabetes[J].Angiology,2015,66(10):918.
[8] Celik A,Ugale S,Ofluoglu H,et al.Metabolic outcomes of laparoscopic diverted sleeve gastrectomy with ileal transposition (dsit) in obese type 2 diabetic patients [J].Obes Surg,2015,25(11):1-5.
[9] Zhou Z,Ju H,Sun M,et al.Serum fetuin-A concentrations are positively associated with serum VEGF levels in patients with newly diagnosed type 2 diabetes[J].Endocr J,2015,62(10):879-885. |
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2018, Vol. 35 
