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| Clinical Significance of Serum miR-130a, HMGA1 and SCC-Ag Expression in Patients with Cervical Cancer |
| HONG Yu |
| Tangshan People's Hospital, Tangshan, Hebei 063001 China |
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Abstract 【Objective】To investigate the clinical significance of serum miR-130a, HMGA1 and SCC-Ag expression in patients with cervical cancer.【Methods】A total of 29 patients with cervical cancer (group A) from March 2016 to June 2017, 32 patients with cervical intraepithelial neoplasia (group B) and 28 healthy volunteers (group C) from March 2016 to June 2017 at our hospital were selected as the subjects of this study. The expression levels of miR-130a, HMGA1 and SCC-Ag in the three groups were compared and analyzed to explore the relationship of miR-130a, HMGA1 and SCC-Ag with clinicopathological features of patients with cervical cancer. ROC curve were used to compare the diagnostic efficacy of miR-130a, HMGA1, SCC-Ag and combined detection in the diagnosis of cervical cancer.【Results】The expression levels of miR-130a, HMGA1 and SCC-Ag in cervical cancer, cervical intraepithelial neoplasia group and healthy control group all showed decreas, and the difference between groups was statistically significant (F miR-130a =78.79, F HMGA1=155.40, FSCC-Ag=79.98, P<0.05).The expression of miR-130a, HMGA1 and SCC-Ag in serum was not related to the age of patients with cervical cancer (P>0.05); however, their expression levels were related to the pathological types of cervical cancer. In addition, miR-130a, HMGA1 and SCC-Ag were highly expressed in squamous cell carcinoma and had low expression in adenocarcinoma (P<0.05).The levels of miR-130a HMGA1 and SCC-Ag were also associated with FIGO stage, which showed high expression in stage III ~ IV and low expression in stage Ⅰ~Ⅱ tumors (P<0.05).The area under the ROC curve of combined detection for diagnosis of cervical cancer was AUC=0.914, 95% CI:0.846 ~ 0.982, and the sensitivity and specificity were 85.19% and 82.35%, respectively, which were higher than those of each index alone. By comparing the area under the ROC curve, it was found that the diagnostic efficiency of combined detection was higher than that of HMGA1 and SCC-Ag alone, and the difference was statistically significant (Z HMGA1=1.99, ZSCC-Ag=2.04, P<0.05). Though AUC combination>AUCmiR-130a, however, the difference was not statistically significant (Z=0.99, P>0.05).【Conclusion】The serum levels of miR-130a, HMGA1 and SCC-Ag in patients with cervical cancer are high, and their expression levels are related to the pathological type and FIGO stage. The combined detection of the three markers has a higher diagnostic value for cervical cancer.
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Received: 26 October 2017
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2018, Vol. 35 
