帕金森病患者睡眠障碍与运动、非运动症状的相关性研究

doi:10.3969/j.issn.1671-7171.2018.03.009

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Abstract 【Objective】To study the correlation between sleep disturbance and motor, non-motor symptoms in patients with Parkinson's disease (PD).【Methods】A total of 265 PD patients with PD from January 2016 to December 2017 were enrolled the study and divided into sleep disturbance group and non-sleep disturbance group according the score of Pittsburgh sleep quality index (PSQI). The baseline data, results of Unified Parkinson's Disease Rating Scale Ⅲ (UPDRSⅢ), H-Y stage, Montreal Cognitive Assessment (MoCA), the Scale For Outcomes in PD For Autonomic Symptoms (SCOPA-AUT), Fatigue Scale-14 (FS-14) and non-motor symptoms scale (NMSS) were compared between the two groups. Pearson correlation coefficient was used to analyze the correlation between PSQI score and other results, and multivariate logistic regression was performed to explore the influencing factors of sleep disturbance.【Results】⑴In all 265 patients, sleep disturbance occurred in 107 cases, whose incidence was 40.4%. There were no significant differences in the baseline data including age, sex, course of disease and onset of disease between the two groups (P<0.05). ⑵The UPDRS-Ⅲ score in sleep disturbance group was significantly higher than that in the non-sleep disturbance group (P<0.05). There was significant difference in H-Y stage between the two groups, and the proportion of stage Ⅴ～Ⅵ in the sleep disturbance group was significantly higher than that in the non-sleep disturbance group (P<0.05). The result of correlation analysis showed that PSQI score of all patients had a significant positive correlation with the UPDRS-Ⅲ score and H-Y stage (r=0.216 and 0.153, P<0.05). ⑶The incidences of non-motor symptoms including orthostatic dizziness, restless legs, losing interest in things around, sad/depression, anxiety/tension, difficult concentrating, loss memory, constipation, unexplained pain and gustatory or olfactory dysfunction, SCOPA-AUT and FS-14 scores in the sleep disturbance group were significantly higher than those in the non-sleep disturbance group, and the MoCA score was significantly lower than that in the non-sleep disturbance group (P<0.05). The result of correlation analysis showed that PSQI scores were positively correlated with SCOPA-AUT and FS-14 scores (r=0.306 and 0.328, P<0.05), and negatively correlated with MoCA score (r=-0.266, P<0.05). ⑷Multivariate logistic regression showed that sad/depression, increased UPDRS-Ⅲ and SCOPA-AUT score were the independent risk factors of sleep disturbance (P<0.05), while increased MoCA score was an independent protective factor (P<0.05).【Conclusion】PD patients have high incidence of sleep disturbance, and it is not only related to motor symptom, but also closely correlated with NMS including depression, autonomic dysfunction and cognitive impairment.

Key words： Parkinson Disease Sleep Disorders Activities of Daily Living Cognition Disorders Depression Autonomic Nervous System Diseases

Received: 22 February 2018

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R322.81

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	CHEN Ze-xin
	HONG Xiang-long
	CHEN Ze-hai

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CHEN Ze-xin,HONG Xiang-long,CHEN Ze-hai. Correlation between Sleep Disturbance and Motor, Non-motor Symptoms in Patients with Parkinson's Disease[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(3): 445-448,452.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.03.009 OR http://www.jcr.net.cn/EN/Y2018/V35/I3/445

[1] 朱军,叶新荣,庄志清,等.UA、LDL-C和TBIL与老年人群帕金森发病或相关性的关系[J].医学临床研究,2017,34(5):991-992.
[2] Alatriste-Booth V,Rodríguez-Violante M,Camacho-Ordoez A,et al.Prevalence and correlates of sleep disorders in Parkinson's disease:a polysomnographic study [J].Arq Neuropsiquiatr,2015,73(3):241-245.
[3] Scullin MK,Fairley JA,Trotti LM,et al.Sleep correlates of trait executive function and memory in Parkinson's disease [J].J Parkinsons Dis,2015,5(1):49-54.
[4] Hughes AJ,Daniel SE,Kilford L,et al.Accuracy of clinical diagnosis of idiopathic Parkinson’s disease.A clinico-pathological study of 100 cases [J].JNNP,1992,55(3):181-184.
[5] 陈海勇,王永军,赵少飞,等.系统心理干预对某警勤连官兵睡眠质量的影响分析[J].转化医学电子杂志,2016,3(11):39-40.
[6] Raggi A,Bella R,Pennisi G,et al.Sleep disorders in Parkinson's disease:a narrative review of the literature [J].Rev Neurosci,2013,24(3):279-291.[7] Svensson E,Beiske AG,Loge JH,et al.Sleep problems in Parkinson's disease:a community-based study in Norway [J].BMC Neurol,2012,12:71.
[8] Diederich NJ,McIntyre DJ.Sleep disorders in Parkinson's disease:many causes,few therapeutic options [J].J Neurol Sci,2012,314(1-2):12-19.
[9] 王雁,杨月嫦,吴惠涓,等.帕金森病患者睡眠的特点及影响因素[J].中华老年心脑血管病杂志,2016,18(7):722-725.
[10] Postuma RB,Aarsland D,Barone P,et al.Identifying prodromal Parkinson's disease:pre-motor disorders in Parkinson's disease [J].Mov Disord,2012,27(5):617-626.
[11] 郭配,张晓韬.帕金森病睡眠障碍的研究进展[J].国际神经病学神经外科学杂志,2017,44(3):332-335.
[12] Aitken D,Naismith SL,Terpening Z,et al.Dysfunctional sleep beliefs in Parkinson's disease:relationships with subjective and objective sleep [J].J Clin Neurosci,2014,21(8):1359-1363.
[13] Iranzo A.Sleep in Neurodegenerative Diseases [J].Sleep Med Clin,2016,11(1):1-18.
[14] Diederich NJ,Rufra O,Pieri V,et al.Lack of polysomnographic Non-REM sleep changes in early Parkinson's disease [J].Mov Disord,2013,28(10):1443-1446.
[15] Neikrug AB,Maglione JE,Liu L,et al.Effects of sleep disorders on the non-motor symptoms of Parkinson disease [J].J Clin Sleep Med,2013,9(11):1119-1129.[16] 王雪梅,冯涛,顾朱勤,等.帕金森病睡眠障碍与非运动症状的相关性研究[J].中华老年心脑血管病杂志,2015,17(5):507-510.
[17] 曹辰杰,余舒扬,左丽君,等.帕金森病患者伴发自主神经功能障碍与运动症状和非运动症状相关性的研究[J].中华临床医师杂志(电子版),2013,7(15):6898-6903.
[18] Chung S,Bohnen NI,Albin RL,et al.Insomnia and sleepiness in Parkinson disease:associations with symptoms and comorbidities [J].J Clin Sleep Med,2013,9(11):1131-1137.
[19] 马红蕾,任艳.帕金森病患者睡眠障碍与认知功能障碍的相关性分析[J].中华临床医师杂志(电子版),2015,9(23):39-45.
[20] 秦朝晖,陈彪,顾朱勤,等.帕金森病患者疲劳与睡眠障碍的研究[J].中风与神经疾病杂志,2016,33(5):388-391.