谷红注射液辅助治疗冠心病患者PCI术后再发心绞痛的临床疗效及其对炎性因子和血管内皮功能的影响

doi:10.3969/j.issn.1671-7171.2018.01.025

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Abstract 【Objective】To investigate the therapeutic effect of Gu Hong Injection on angina pectoris after percutaneous coronary intervention (PCI) in patients with coronary heart disease and its influence on inflammatory reaction and vascular endothelial function.【Methods】From January 2014 to December 2016, 114 patients with angina pectoris treated by PCI operation in our hospital were selected.According to the random number method; they were divided into observation group and control group with 57 cases in each group. Patients in the control group were treated with aspirin enteric-coated tablets, clopidogrel sulfate tablets, isosorbide mononitrate tablets and metoprolol tartrate tablets. The observation group was treated with Gu Hong Injection on the basis of the use of the control group. All the patients were treated for 2 weeks. The frequency and duration of angina pectoris before and after treatment were compared between the two groups. The therapeutic effect of angina pectoris was evaluated. Levels of serum Hs-CRP, tumor necrosis factor -α (TNF-α), interleukin-6 (IL-6) and endothelin-1 (ET-1) and nitric oxide (no) were compared between the two groups before and after treatment. At the same time, Doppler color ultrasound was used to evaluate vascular endothelium-dependent diastolic (FMD) function.【Results】After treatment, the attack frequency and duration of angina pectoris in the two groups were lower than those before treatment, and the attack frequency and duration of angina pectoris in the observation group were significantly lower than those in the control group. The difference was statistically significant (P<0.05). The total effective rate of treatment in the observation group was 91.2% (52/ 57), which was significantly higher than that in the control group 82.5% (47/ 57), and the difference was statistically significant (χ²=5.368, P<0.05). After treatment, the levels of serum Hs-CRP, TNF-and IL-6 were significantly decreased in both groups. The level of serum Hs-CRP, TNF-and IL-6 in the observation group was significantly lower than that in the control group (P<0.05). After treatment, the serum ET-1 level in the two groups was significantly decreased, the levels of NO and FMD increased significantly; the serum ET-1 level in the observation group was significantly lower than that in the control group. The NO and FMD were significantly higher than those of the control group, the difference was statistically significant (P<0.05). 【Conclusion】On the basis of routine treatment after PCI operation for coronary heart disease, Guhong injection significantly reduce the frequency of recurrent angina pectoris after PCI and the level of serum inflammatory factors, and improve vascular endothelial function.

Key words： Coronary Disease Angioplasty, Transluminal, Percutaneous Coronary Angina Pectoris BLOOD ACT STASIS REMOV AGENTS/TU INJECTIO Tumor Necrosis Factor-alpha C-Reactive Protein Endothelium, Vascular

Received: 22 November 2017

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FU Qiang,QI Ji. Therapeutic Effect of Gu Hong Injection on Angina Pectoris after PCI in Patients with Coronary Heart Disease and its Influence on Inflammatory Reaction and Vascular Endothelial Function[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(1): 79-82.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.01.025 OR http://www.jcr.net.cn/EN/Y2018/V35/I1/79

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