脑脊液中游离脂肪酸水平在急性缺血性脑卒中的预后价值

doi:10.3969/j.issn.1671-7171.2018.01.023

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (0 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To evaluate the prognostic value of free fatty acid (FFA) levels in cerebrospinal fluid (CSF) of patients d with acute ischemic stroke (AIS).【Methods】A total of 321 cases of acute ischemic stroke patients from January 2012 to December 2015 in our hospital were selected as study subjects. The National Institutes of Health Stroke Scale (NIHSS) score on admission was applied to assess specific severity degree of stroke. The levels of FFA from CSF and serum were measured using an enzyme cycling method. The prognostic outcomes of those stroke patients were evaluated by the modified Rankin scale scores 90days after admission. The prognostic value of FFA was analyzed by Logistic regression analysis.【Results】There was a positive relationship between CSF FFA and NIHSS score.Additionally, there was a positive relationship between the severity of stroke and serum levels of FFA. The FFA levels of CSF and serum in 231 patients with favorable outcome were significantly lower than those in 90 patients with unfavorable outcomes (P<0.05). The FFA levels of CSF and serum in 272 cases of survival patients were significantly lower than those in 49 dead patients (P<0.05). Multivariate analysis results showed that there was an increased risk of unfavorable outcome associated with FFA level in CSF ≥0.301 mmol/L (OR=5.28, P<0.0001).【Conclusion】The FFA level in CSF at admission was suggested to be an independent short-term prognostic marker in patient with AIS.

Received: 07 November 2016

PACS:

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.01.023 OR http://www.jcr.net.cn/EN/Y2018/V35/I1/73

[1] Ebbert JO,Jensen MD.Fat depots,free fatty acids,and dyslipidemia[J].Nutrients,2013,5(2):498-508.
[2] Seo WK,Kim JK.Elevated free fatty acid is associated with cardioembolic stroke subtype[J].Can J Neurol Sci,2012,38(6):874-879.
[3] 林晖.急性缺血性脑卒中的发病机制及治疗进展[J].内科,2012,7(5):540-542.
[4] 饶明俐.中国脑血管病防治指南[J].中风与神经疾病杂志,2005,22(6):484-487.
[5] 刘伯芹,王国峰.bFGF和PDGF-B蛋白在脑缺血再灌注大鼠模型中的表达和血管形成的研究[J].卒中与神经疾病,2015,7(5):540-542.
[6] Ahmcd Ashrafi SK,Suhail Z,Khambaty Y.Postembolization infarction in juvenile nasopharyageal angiofibroma[J].J Coll Phsicians Surg Pak,2011,21(2):115-116.
[7] Choi JY,Kim JS.High free fatty acid level is associated with recurrent stroke in cardioembolic stroke patients[J].Neurology,2014,82(13):1142-1148.
[8] Yaemsiri S,Sen S.Serum fatty acids and incidence of ischemic stroke among postmenopausal women[J].Stroke,2013,44(10):2710-2717.
[9] Selnes P,Blennow K.Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid[J].Cerebrospinal Fluid Res,2010,7:10.
[10] Steiner J,Bielau H.Increased cerebrospinal fluid and serum levels of S100B in first-onset schizophrenia are not related to a degenerative release of glial fibrillar acidic protein,myelin basic protein and neurone-specific enolase from glia or neurones[J].J Neurol Neurosurg,2006,77(29) 1284-1287.
[11] Brouns R,De Vil B,et al.Neurobiochemical markers of brain damage in cerebrospinal fluid of acute ischemic stroke patients[J].Clin Chem,2010,56(3):451-458.
[12] 许春华,刘明,陈超.阿托伐他汀对高血压脑出血患者血清神经元特异性烯醇化酶和S100B蛋白的影响及疗效[J].中国实用神经疾病杂志,2015,18(18):106-107.
[13] Tu WJ,Dong X.Prognostic value of plasma neuroendocrine biomarkers in patients with acute ischaemic stroke[J].J Neuroendocrinol,2013,25(9):771-778.

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(1): 205-207.