七氟醚对肺癌根治术患者血清E-选择素、基质金属蛋白酶及免疫功能的影响

doi:10.3969/j.issn.1671-7171.2018.01.018

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Abstract 【Objective】To investigate the effect of inhalation anesthesia on E-selectin, matrix metalloproteinase (MMP) and immune function recovery in patients with lung cancer .【Methods】Eighty-six cases of radical resection of lung cancer were selected in our hospital and were randomly divided into sevoflurane group (n=43) and isoflurane group (n=43). The levels of E-selectin, MMP-2, MMP-9, interleukin-6 (IL-6), tumor necrosis factor -ɑ and soluble interleukin-2 receptor (sIL-2R) were monitored and compared at the time of anesthesia induction (T₀), 1h after operation start (T₁), 2h (T₂) and 1h after operation (T₃).【Results】The serum levels of E-selectin, MMP-2, MMP-9 and TNF-ɑ in the group A were lower than those in group B at time of T₁、T₂、T₃ (P<0.05). The level of serum IL-6 in the group A was lower than that in group B at time of T₁, T₂ and T₃ (P<0.05).There was no significant difference in the level of sIL-2R between the two groups at each time point (P>0.05).【Conclusion】Sevoflurane inhalation anesthesia can effectively inhibit the increase of E-selectin, MMP-2 and MMP-9, which is beneficial to the recovery of the immune function of the patients.

Key words： Ethers/PD Lung Neoplasms/SU E-Selectin/DE Matrix Metalloproteinases/DE Immunity/DE

Received: 30 December 2016

PACS:

R734.2

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Cite this article:

WANG Hua. Effects of Inhalation Anesthesia on E-selectin , Matrix Metalloproteinase (MMP) and Immune Function Recovery in Patients with Lung Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(1): 59-61.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.01.018 OR http://www.jcr.net.cn/EN/Y2018/V35/I1/59

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(1): 111-113.