点阵激光联合复方倍他米松注射液对增生性瘢痕患者血清TGF-β1、BMP-7、EGF水平变化及预后的影响

doi:10.3969/j.issn.1671-7171.2018.01.010

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Abstract 【Objective】To investigate the effects of dot matrix laser combined with compound betamethasone injection on serum transforming growth factor-β1 (TGF-β1), bone morphogenetic protein-7 (BMP-7), epidermal growth factor (EGF) levels and prognosis in patients with hypertrophic scar (HS).【Methods】From January 2013 to October 2016, 98 patients with HS in our hospital were selected and divided into control group and observation group according to the treatment plan, 49 cases in each group. The control group was given simple dot matrix laser treatment, the observation group received compound betamethasone injection treatment on the basis of the control group. The serum TGF-β1, BMP-7, EGF levels, negative emotions [ (SAS) and depression (SDS)] scores before and after treatment and post-treatment scar (VSS) scores after treatment were compared between the two groups, and the incidence of adverse reactions was statistically analyzed.【Results】 (1)Serum-related factors: Before treatment, the serum TGF-β1, BMP-7 and EGF levels were not statistically significant between the two groups (P>0.05).But after treatment, the serum TGF-β1 and EGF levels in the observation group were significantly lower than those in the control group and BMP-7 was significantly higher than that in the control group (P<0.05); (2) Scar score: The VSS each dimension scores in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05); (3) Adverse reactions: There was no significant difference in the incidence of adverse reactions between the observation group 12.24% (6/49) and the control group 10.20% (5/49) (P>0.05). (4) negative emotions: Before treatment, the SAS, SDS scores of the two groups were no significant difference (P>0.05), after treatment, the SAS and SDS scores in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05).【Conclusion】Treatment of HS using dot matrix laser combined with betamethasone injection can effectively improve the serum TGF-β1, BMP-7 and EGF levels, promote the scar to subside with safety, it is helpful to alleviate and eliminate the negative emotions.

Key words： Laser Therapy Betamethasone/PD Drug Combinations INJECTIO Cicatrix Transforming Growth Factor beta1/BL Bone Morphogenetic Proteins/BI Epidermal Growth Factor/AN

Received: 22 March 2017

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R619.6

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	Articles by authors
	ZHANG Xiao-gang
	MA Chi-jiao
	WU Tian-gang
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ZHANG Xiao-gang,MA Chi-jiao,WU Tian-gang, et al. Effects of Dot Matrix Laser Combined with Compound Betamethasone Injection on Serum TGF-β1, BMP-7, EGF Level Changes and Prognosis in Patients with Hypertrophic Scar[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(1): 33-36.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.01.010 OR http://www.jcr.net.cn/EN/Y2018/V35/I1/33

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