血清REG4和CA19-9在早期胃癌患者中的表达及其意义

doi:10.3969/j.issn.1671-7171.2018.01.008

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Abstract 【Objective】To explore the expression levels of serum regenerated gene protein 4 (REG4) and carbohydrate antigen 19-9 (CA19-9) in patients with early gastric cancer.【Methods】A total of 90 cases of patients diagnosed with early gastric cancer from June 2015 to June 2016 in our hospital were selected as the observation group and 90 healthy persons in the same time frame were selected as the control group. Blood samples from the two groups were collected. The serum REG4 expression levels were detected by enzyme linked immunosorbent assay (ELISA) and the serum CA19-9 expression levels were detected by chemiluminescence immunoassay. The histopathological parameters of tumor staging, tissue type, differentiation degree and distribution were determined by gastroscopy and histopathological examination. The serum REG4 and CA19-9 levels were then compared between the two groups. The relationships between the levels of serum REG4and CA19-9 with different gender, age and other pathological parameters in the observation group were analyzed.【Results】The levels of serum REG4 and CA19-9 in the observation group were significantly higher than those in the control group (P<0.05). The levels of serum REG4 and CA19-9 in stage Ⅰb patients were significantly higher than in stage Ⅰa patients (P<0.05). The levels of RGE4 and CA19-9 in the patients of highly differentiated were significantly higher than those in the moderately differentiated, while the patients of moderately differentiated were significantly higher than those in the low/undifferentiated (P<0.05). The levels of serum RGE4 and CA19-9 were significantly higher in the patients with tumor cells that infiltrated the submucosa than those inwith tumor cells that infiltrated the mucosa (P<0.05). The serum levels of RGE4 and CA19-9 in the patients of tumor diameter of ＞3 cm were significantly higher than in patients with tumor diameter of 2~3 cm (P<0.05); the patients with tumor diameter of 2~3 cm had significantly higher than serum levels of those with tumor diameter of 1~2 cm; the patients with tumor diameter of 1~2 cm had significantly higher serum levels than those with tumor diameter of <1 cm (P<0.05). There were no significant differences in REG4 and CA19-9 expression with differing gender, age, tissue type and tumor distribution (P>0.05).【Conclusion】The serum REG4 and CA19-9 levels are significantly elevated in early gastric cancer patients and are closely associated with tumor staging, differentiation degree, infiltration depth, and tumor size.

Key words： CA-19-9 Antigen Stomach Neoplasms/PA Early Diagnosis Neoplasm Staging

Received: 13 November 2017

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R735.2

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	ZHU Yan
	HUANG Shu-ling

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ZHU Yan,HUANG Shu-ling. Effect of Expression Levels of Serum Regenerating Gene Protein 4 and Carbohydrate Antigen19-9 in Patients with Early Gastric Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(1): 26-29.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.01.008 OR http://www.jcr.net.cn/EN/Y2018/V35/I1/26

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