谷氨酸受体拮抗剂对电休克后抑郁大鼠记忆障碍的影响

doi:10.3969/j.issn.1671-7171.2018.01.001

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Abstract 【Objective】To investigate the effect of glutamate (Glu) receptor antagonist on memory impairment in rats after electroconvulsive shock (ECT).【Methods】A total of 24 healthy male SD rats were randomly divided into the blank group, ECT group and MK-801+ECT group, with 8 rats in each group. Rats in the blank group were injected with normal saline 2 mL, and rats in the ECT group were treated with ECT. Rats in the MK-801+ECT group were injected with 2 mL MK-801 into their tail veins before ECT. Morris water maze learning and memory tests were used to explore memory impairment in rats, and the content of Glu and GABA in rat brain was determined by HPLC.【Results】The escape latency of ECT and MK-801+ECT groups was significantly longer than that of the blank group (t=7.708, 3.408, P<0.05), and the escape latency of the MK-801+ECT group was significantly shorter than that of ECT group; there was statistical difference (t=5.137, P<0.05). The percentage of swimming rats in the ECT and MK-801+ECT groups decreased significantly compared to the control group (t=12.039, 4.886, P<0.05). However, the percentage of swimming rats in the MK-801+ECT group was significantly higher than that in the ECT group, and the difference was statistically significant (t=7.543, P<0.05). The number of rats passing through the original platform in the ECT and MK-801+ECT groups decreased significantly compared to that in the blank group (t=9.459, 2.156, P<0.05). In addition, the number of rats passing through the original platform in the MK-801+ECT group was significantly higher than that in the ECT group, and there was statistical difference (t=9.508, P<0.05). Glu and GABA content levels in the ECT and MK-801+ECT groups rat brain were significantly higher than those in the blank group, and there were significant differences (ECT group: t=6.701, 5.639, MK-801+ECT group: t=2.630, 2.233, P<0.05). The Glu and GABA contents in the brain of rats in the MK-801+ECT group were significantly lower than in the ECT group, and there was statistical difference (t=4.789, 3.881, P<0.05).【Conclusion】Glu receptor antagonist MK-801 can alleviate the memory impairment in rats after electroconvulsive therapy as well as reduce the content of Glu and GABA in the brain, which has important research significance.

Key words： Receptors, Glutamate Electroshock/AE Depression/ET Memory Disorders

Received: 23 November 2017

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R749.42

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	YAO Zhu-wei
	ZHANG Meng
	ZHOU Xiao-qin
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YAO Zhu-wei,ZHANG Meng,ZHOU Xiao-qin, et al. Effect of Glu Receptor Antagonist on Memory Impairment in Rats after Electroconvulsive Shock[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(1): 1-3,7.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.01.001 OR http://www.jcr.net.cn/EN/Y2018/V35/I1/1

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