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| Relationship between 1h Post-Load Plasma Glucose Elevation and Carotid Intima-Media Thickness in Obese Women with Normal Glucose Tolerance |
| LU Qiang, ZHU Dong-lin, Wang Rui, et al |
| First Hospital of Qinghuangdao, Hebei, 066000, China |
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Abstract 【Objective】To explore the relationship between 1h post-load plasma glucose (1hPG) elevation and carotid intima-media thickness (CIMT) in obese women with normal glucose tolerance (NGT) .【Methods】A total of 186 women who underwent physical examination in our hospital (May to December, 2014) were collected for the study. They were 18-57 years old with NGT. According to the body mass index (BMI) , all cases were divided into normal (n=82) , overweight (n=63) and obese (n=41) groups. All subjects underwent an oral glucose tolerance test (OGTT) and CIMT. The levels of blood glucose and insulin (INS) were compared among the three groups. Furthermore, the correlation between 1hPG and CIMT was analyzed.【Results】Systolic blood pressure (SBP) , triglyceride (TG) and CIMT in the obese group were higher than those in the normal group (P<0.05) . Insulin resistance index (HOMA-IR) in the obese group was higher than that in the overweight group (P<0.05) . Serum 1hPG, 0hINS and 1hINS levels in the obese group were significantly higher than those in the normal group, and serum 0hINS and 1hINS levels were significantly higher than those in the overweight group. All differences were statistically significant (P<0.05) . Other parameters (0.5hPG, 1 hPG, 2hPG, 3hPG, 0.5hINS, 2hINS and 3hINS) in the three groups were not statistically significant. CIMT was correlated with BMI (r=0.316, P=0.001) , fasting plasma glucose (FPG) (r=0.328, P<0.328) , and 1hPG (r=0.263, P=0.005) , (all P<0.05) . Multiple linear regression showed that 1hPG, age and BMI had a significant positive correlation with CIMT (P<0.05) .【Conclusion】Obese women with normal glucose tolerance have 1hPG, 1hINS and insulin resistance. 1hPG is an independent risk factor for carotid intima-media thickening (CIMT) .
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Received: 30 June 2017
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2017, Vol. 34 
