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| Clinical Analysis and Review of 14 Cases with Sinonasal Neuroendocrine Carcinoma |
| ZENG Tian, LI Jian-jun |
| Department of Oncology, The First affiliated Hospital of Army Medical University, Chongqing China, 400038 |
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Abstract 【Objective】To investigate the clinical performance, pathological characteristics, treatment and prognosis of sinonasal neuroendocrine carcinoma.【Methods】A retrospectively study was carried out among 14 cases with this tumor treated in the First Affiliated Hospital of Army Medical University from October 2007 to August 2015 through a careful analysis on their clinical data, the clinical characteristics and treatment of the disease was studied on reviewing the relevant literature.【Results】All of the 14 cases were confirmed pathologically as small cell neuroendocrine carcinoma: 3 cases were lost to follow-up, 1 case died 1 month after treatment; 1 case had liver metastasis 5 months after treatment, no treatment, and died after 11 months of follow-up; Tumor bearing survival in 4 cases; Local recurrence occurred in 1 case after 11 months of treatment and had no treatment. The patient was followed up for 109 months and the condition was stable; Local recurrence occurred in 1 case 60 months after treatment, and was followed up for 67 months, now in the local radiotherapy; Brain metastasis occurred in 1 patient after 32 months of treatment, followed by cranial radiotherapy and chemotherapy. The patient was followed up for 44 months and the condition was stable; 1 case was followed up for 24 months, the condition was stable, no tumor survived in 5 cases, followed up for 24~89 months, and did not suggest local recurrence and distant metastasis of tumor.【Conclusion】The incidence of this disease is low, the diagnosis mainly depends on histopathologic manifestations, immunohistochemical results and ultrastructure under electron microscope characteristics; it should be differentiated from the poorly differentiated squamous carcinoma, melanoma and olfactory nerve blastoma and neurospongioma; Early diagnosis, tumor staging, extent of invasion, with or without surgery and combination of chemotherapy and radiotherapy are the prognostic factors of the disease.
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Received: 09 May 2017
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2017, Vol. 34 
