剪切波弹性成像和血清肝纤维化标志物检测对婴儿肝炎综合征肝纤维化的预测价值

doi:10.3969/j.issn.1671-7171.2017.11.012

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Abstract 【Objective】To investigate the value of shear wave elastography (SWE) and serum markers of hepatic fibrosis in predicting hepatic fibrosis in infantile hepatitis syndrome (IHS) .【Methods】Sixty infants with IHS diagnosed in our hospital from March 2016 to May 2017 were selected as the subjects, According to the staging criteria of chronic hepatitis fibrosis, it is divided into S1~4 stage, At the same time, 20 healthy infants were selected as control group. Liver stiffness (LS) was detected by SWE, and serum markers of liver fibrosis were detected in children.【Results】Age, hemoglobin (HB) , total bilirubin (TB) , hyaluronic acid (HA) , type Ⅳ collagen (Ⅳ -C) , LS were significantly correlated with the degree of liver fibrosis (P<0.05) , and HB was negatively correlated with liver fibrosis, and the others were significantly positively correlated. There was a significant positive correlation between HA, Ⅳ-C, LS and liver fibrosis (P<0.01) . Aspartate aminotransferase (AST) , alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) were not significantly correlated with liver fibrosis stages (P>0.05) . Compared with HA and Ⅳ-C, the detection of LS with SWE showed the highest curve area in mild fibrosis, moderate fibrosis and severe fibrosis analysis, followed by 0.866, 0.904 and 0.893. In the ROC curve analysis of mild fibrosis, the area under the HA curve (0.837) was greater than that of Ⅳ-C (0.716) , In the ROC curve of moderate fibrosis and high fibrosis, the area under the Ⅳ-C curve was 0.812 and 0.854, respectively, which were higher than those of HA (0.722 and 0.830) respectively.【Conclusion】SWE and serum markers of liver fibrosis (HA and Ⅳ-C) have good diagnostic efficacy in infants with IHS liver fibrosis, and SWE is superior to serum markers of liver fibrosis.

Key words： Elasticity Imaging Techniques/MT Liver Cirrhosis/BL Hepatitis/BL Biological Markers/BL Syndrome

Received: 03 July 2017

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R575.1

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	PENG Ya
	DUAN Xing-xing
	LIU Jin-qiao
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PENG Ya,DUAN Xing-xing,LIU Jin-qiao, et al. Predictive Value of Shear Wave Elastography and Serum Markers of Hepatic Fibrosis in Hepatic Fibrosis of Infantile Hepatitis Syndrome[J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(11): 2116-2119,2123.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.11.012 OR http://www.jcr.net.cn/EN/Y2017/V34/I11/2116

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