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| Synergistic Effect of Dexmedetomidine (Dex) Combined with Flurbiprofen Axetil on Postoperative Hyperalgesia Induced by Remifentanil |
| LIU Xing-wei |
| Department of Anesthesiology, Deyang People's Hospital, Sichuan, Deyang 618000, Sichuan, China |
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Abstract 【Objective】To analyze the synergistic effect of dexmedetomidine (Dex) combined with flurbiprofen axetil on postoperative hyperalgesia induced by remifentanil.【Methods】One hundred patients scheduled for gynecological laparoscopic surgery were randomly divided into three groups. Remifentanil anesthesia was used in all patients. Before anesthesia induction, the group A was not given drugs, the group B received Dex infusion and the group C received Dex combined with flurbiprofen intravenous injection. Mechanical pain threshold around umbilicus, the static visual analogue scale (VAS) , 24h sensitive area around the umbilicus after operation, the dosage of sufentanil and the incidence of adverse reactions at different time points were compared among the groups.【Results】The mechanical pain thresholds around umbilicus of 1h, 6h and 24h in the group and B and the group C were significantly higher than those in the group A after operation (P<0.05) . At postoperative 0.5h, 1h, 6h, 24h, resting VAS, seven halothane concentration, postoperative 24h sufentanil dosage and the sensitive area of umbilicus pain were significantly lower than those in the group A (P<0.05) ; the above indexes in the group C were significantly better than those in the group B (P<0.05) . The incidence of postoperative hypotension and bradycardia in the group B and C were significantly higher than those in the group A; nausea, vomiting and the incidence of postoperative shivering were significantly lower than those in the group A (P<0.05) , but there was no significant difference between the group B and C (P>0.05) .【Conclusion】Dex is good at preventing postoperative hyperalgesia induced by remifentanil. It can significantly reduce the dosage of remifentanil, but is prone to cause hypotension and bradycardia. Its combination with flurbiprofen can not only enhance the synergistic effects in reducing postoperative hyperalgesia but also decrease the adverse reactions.
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Received: 22 February 2017
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2017, Vol. 34 
