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| CyclinD1 and P16 Expression and the Clinicopathological Significance in Human Nasopharyngeal Carcinoma |
| WEI Mei-yan, CHEN Hui, DUAN Zhi, et al |
| Department of Pathology, The First Hospital of Changsha, Hunan Province, Changsha 410005 |
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Abstract 【Objective】To investigate the expression of CyclinD1 and P16 in patients with nasopharyngeal carcinoma (NPC) .【Methods】A total of 70 patients with NPC and 55 patients with chronic rhinitis in our hospital from Jan. 2009 to Dec. 2015 were selected. The expression of P16 and CyclinD1 protein in NPC and chronic rhinitis tissue were detected by SP immunohistochemistry, and the gene loss of p16 in patients of NPC was detected by polymerase chain reaction (PCR) .【Results】Positive expression rate of CyclinD1 in the NPC group was higher than that of the chronic rhinitis group; and the difference between the two groups was statistically significant (P＜0.05) . Positive expression rate of P16 in the NPC group was lower than that of the chronic rhinitis group; and the difference was statistically significant (P＜0.05) . Positive expression rate of CyclinD1 in the T3~T4 stage patients was significantly higher than that of the T1~T2 stage patients (P＜0.05) . Positive expression rate of CyclinD1 in the N1~3 stage patients was significantly higher than that of the N0 stages patients (P＜0.05) . Positive expression rate of CyclinD1 in the Ⅲ~Ⅳ stage patients was significantly higher than that of the Ⅰ~Ⅱ stage patients (P＜0.05) . Positive expression rate of P16 in the T3~T4 stage patients was significantly lower than that of the T1~T2 stage patients (P＜0.05) . Positive expression rate of P16 in the N1~3 stage patients was significantly lower than that of the N0 stage patients (P＜0.05) . Positive expression rate of P16 in the Ⅲ~Ⅳ stage patients was significantly lower than that of the Ⅰ~Ⅱ stage patients (P＜0.05) . The rate of p16 gene loss in NPC (34.3％) was significantly higher than that of the chronic rhinitis group (1.8%) ; and the difference was statistically significant (P＜0.05) .【Conclusion】Higher expression of CyclinD1, the loss of p16 gene and the lower expression of P16 were associated with the occurrence and prognosis of NPC.
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Received: 17 March 2017
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2017, Vol. 34 
