MiR-375、Bcl-2基因在乳腺癌中的表达及其意义

doi:10.3969/j.issn.1671-7171.2017.11.003

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Abstract 【Objective】To investigate the expression and significance of miR-375 and Bcl-2 genes in breast cancer.【Methods】The expression of miR-375 and Bcl-2 mRNA in 48 cases of breast cancer and 48 cases of adjacent breast cancer tissues were detected by real-time quantitative PCR, The differential expression and correlation of miR-375 and Bcl-2 mRNA in different clinicopathological parameters of breast cancer were analyzed.【Results】Compared with adjacent breast cancer tissues, miR-375 and Bcl-2 mRNA showed significantly lower expression and high expression in breast cancer tissues (P<0.05) , respectively, and the expression of Bcl-2 mRNA was negatively correlated with the expression of miR-375 (r=-0.648, P<0.05) . In addition, the expression of Bcl-2, mRNA and miR-375 was significantly correlated with lymph node metastasis in breast cancer (P<0.05) .【Conclusion】MiR-375 may promote the progression of breast cancer by targeting Bcl-2 mRNA, and affect the prognosis of patients with breast cancer.

Key words： MicroRNAs Genes, bcl-2 Breast Neoplasms/GE Breast Neoplasms/PA Prognosis

Received: 15 March 2017

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R737.9

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	LU Dan

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LU Dan. Expression and Significance of miR-375 and Bcl-2 Genes in Breast Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(11): 2088-2090,2094.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.11.003 OR http://www.jcr.net.cn/EN/Y2017/V34/I11/2088

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