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| Effect of Postoperative Chemotherapy Combined with Endocrine Therapy on the Expression of ERβ in Cancer Tissues of Advanced Prostate Cancer |
| WANG Jin-en, CHENG Fan |
| Remin Hospital of Wuhan University ,Wuhan, Hubei, 430060, China |
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Abstract 【Objective】To investigate the effect of postoperative chemotherapy combined with endocrine therapy on the advanced prostate cancer and the correlation of ERβ expression in cancer tissues.【Methods】A total of 120 patients with advanced prostate cancer were treated in our hospital from January 2015 to March 2017, and randomly divided into the experimental group and the control group, 60 cases in each group . The experimental group received chemotherapy and endocrine therapy, and the control group received routine chemotherapy. The curative effect difference between the two groups was observed. The correlation between the effect of treatment and the expression of ERβ in cancer tissue was analyzed according to the difference between the two groups.【Results】The effective rate of the prostate cancer patients in the experimental group was significantly higher than that of the control group, the difference was statistically significant (χ2=9.219,P＜0.05). The expression levels of ERβ in cancer tissues were lower in the effective patients of experimental group, the control group and the two groups than those of ineffective patients. The difference was also statistically significant (P＜0.05). According to the expression of ERβ in cancer tissue level and efficacy of single factor logistics regression analysis, the differences were statistically significant (P＜0.05), the maximum likelihood estimates of cancer ERβand OR＜0, which suggested that cancer ER beta expression levels were negatively correlated with the curative effect.【Conclusion】Postoperative chemotherapy combined with endocrine therapy is effective in the treatment of middle and advanced prostate cancer. The effect is negatively correlated with the expression of ER βbeta in cancer tissues.
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Received: 04 July 2017
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2017, Vol. 34 
