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| Expression of CD133 and MVD in Triple-Negative Breast Cancer |
| YU Hong, LI Xiao-xing, JIA Xiao-min |
| Department of Pathology, Hunan Provincial People's Hospital, Changsha, Hunan 410005 |
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Abstract 【Objective】To detect the expression of tumor stem cell marker CD133 and micro vessel density (MVD) in triple negative breast carcinoma (TNBC), and to analyze their clinical value.【Methods】A total of 41 patients with triple-negative breast cancer were enrolled in our hospital from January 2010 to January 2012 for this study. CD133 expression and MVD count were measured by immunohistochemical method ElivisionTM plus, and the follow-up data of all patients were arranged and analyzed.【Results】There were significant differences in age, menstrual status, lymph node metastasis and histological grade between TNBC patients and non - TNBC patients
(P<0.05).However, there were no significant differences in tumor size, pathological type and clinical stage (P>0.05). Out of the total 41 TNBC cases, 18 had CD133 positive expression, accounting for 43.90% of the total samples. In these cases, the tumor size, clinical stage and lymph node metastasis were closely related to the positive rate of CD133 (P<0.05). The mean MVD count of TNBC patients was (20.95 ± 7.8) which was significantly higher than that of non-TNBC group (15.02 ± 9.3); the difference was significant (t=3.916, P<0.05).MVD counts in lymph node metastasis and clinical staging were statistically significant (P<0.05). The MVD value of CD133 positive in TNBC patients was (23.34 ± 8.4), which was significantly higher than that of CD133 negative (18.11 ± 5.5), and the difference was significant (t=2.403, P<0.05). The mean time of disease-free survival (DFS) and overall survival (OS) time of CD133 positive expression in TNBC were (25.5 ± 3.6) months and (32.3±2.5) months, respectively. These were significantly lower than those of CD133 negative expression in TNBC DFS (58.2 ± 4.2) months and OS (54.6 ± 3.3) months, respectively; The difference was significant (P<0.05). In this study, the median value of MVD in 41 patients with TNBC was 21. Our results showed that the 3-year and 5-year survival rates of MVD≥21 were significantly lower than those of MVD<21; the difference was significant (P<0.05 ).【Conclusion】CD133 expression and MVD count are closely related to lymphatic metastasis and clinical stage in TNBC patients. Therefore, the clinical progress and prognosis of TNBC patients can be determined by measuring CD133 expression and MVD count and is worthy of clinical application.
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Received: 01 April 2017
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2017, Vol. 34 
