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| Expression of MIF and Cyr61 in Gingival Carcinoma and Potential Clinical Application |
| WANG Jing, WU Ying-ying, HUO Feng, et al |
| Department of Stomatology, Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China |
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Abstract 【Objective】To explore the expression of macrophage migration inhibitory factor (MIF) and cysteine-rich 61 (Cyr 61) in gingival carcinoma and their clinical application.【Methods】A total of 58 patients with gingival carcinoma treated in our hospital from April 2012 to July 2016 were recruited for the study. Tumor tissues from all 58 cases were collected along with 11 cases of randomly picked adjacent normal gingival tissues among those 58 patients. The expression of MIF and Cyr61 was determined by immunohistochemical staining method, and the clinical data and pathological features of patients were summarized.【Results】The positive expression rate of MIF in gingival carcinoma tissues was found to be 70.7% (41/58), which was significantly higher than that in adjacent normal tissues 36.4%(4/11). The positive expression rate of Cyr61 in gingival carcinoma tissues was 89.7% (52/58), which was significantly higher than that in the adjacent normal tissues 54.5% (6/11). The positive expression of MIF and Cyr61 had no obvious correlation with the age and gender of patients, while they had a significant positive correlation with the differentiation degree of gingival carcinoma and lymph node metastasis. Both MIF and Cyr61 were positive in 37 cases (63.8%). There was a positive correlation between MIF and Cyr 61 (r=0.355, P<0.05).【Conclusion】The expression levels of MIF and Cyr61 are high in gingival carcinoma tissues and they are correlated with tumor differentiation and lymphatic metastasis. MIF and Cyr 61 are positively correlated with each other, which can be used as a reference index for clinical diagnosis and treatment of gingival carcinoma.
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Received: 05 April 2017
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[1]张劲男,张光波,乔军利,等.慢病毒介导的siRNA干扰乳腺癌MCF-7细胞MIF对VEGF-C表达的影响[J].临床与实验病理学杂志,2015,31(12):1388-1391.
[2]Jun LI,Lin YE,Owen S,et al.Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)[J].Int J Mol Med,2015,36(6):1451-1463.
[3]赵然,姚伟娟.巨噬细胞迁移抑制因子的功能及临床研究进展[J].生理科学进展,2014,45(2):93-99.
[4]付东梅,李立方,康玉华.人胃癌组织中巨噬细胞移动抑制因子和VEGF的表达及其临床意义[J].中国肿瘤生物治疗杂志,2014,21(4):455-458.
[5]王秋锐,杨健,赵华平,等.雌激素受体及芳香化酶在牙龈癌组织中的表达和意义[J].牙体牙髓牙周病学杂志,2015,25(5):304-307.
[6]Piszczatowski RT,Lents NH.Regulation of the CCN genes by vitamin d:a possible adjuvant therapy in the treatment of cancer and fibrosis [J].Cell Signal,2016,28(10):1604-1613.
[7]吴聪莲,祝先进,曹颖平.Cyr61在肿瘤中的作用及临床应用前景[J].中华检验医学杂志,2016,39(8):571-574.
[8]季君,程铖,周军,等.Cyr61在原发性肝细胞癌中的表达及其临床意义[J].现代免疫学,2013,33(3):208-212.
[9]程伟,张雄,黄捷,等.CCN1基因在肾癌组织中的表达及其意义[J].重庆医学,2012,41(3):244-245. |
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2017, Vol. 34 
