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| Value of Neoadjuvant Interventional Chemotherapy in the Treatment of Locally Advanced Cervical Cancer and Its Effect on Cytokine Expression |
| DAI Gui |
| Hunan Provincial Maternity and Child Health Care Hospital, Changsha 410008, China |
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Abstract 【Objective】To investigate the value of neoadjuvant interventional chemotherapy in the treatment of locally advanced cervical cancer and its effect on the expression of MMP-2, Fas and FasL cytokines.【Methods】A total of 60 cervical cancer patients in stage of IB ~ IIB, with tumor diameters greater than 4 cm were chosen for the study. They were randomly divided into groups A and B, each with 30 subjects. Patients in group A was treated with artery interventional neoadjuvant chemotherapy plus radical surgery, while patients in group B were treated with conventional intravenous chemotherapy plus radical surgery. The efficacy and occurrence of side effects were observed. The expression of MMP-2, Fas and FasL cytokines in two groups both before and after treatment was detected by immunohistochemistry.【Results】The effective rate of group A (83.33%) was significantly higher than that of group B (73.33%) (χ2=2.116, P=0.045). The effective rate of Ib was significantly higher than that of IIa and IIb; IIa was significantly higher than that of IIb; the effective rate of chemotherapy in patients with squamous cell carcinoma was significantly higher than that of adenocarcinoma; the efficiency of low differentiation of cervical cancer was significantly higher than that of middle differentiation and high differentiation (P<0.05). In group A, there were 14 cases of chemotherapy side effects, including vomiting /nausea (6 cases), moderate anemia (2 cases), hypogastrium pain (4 cases) and alopecia (2 cases). Group B had a total of 11 cases of side effects, consisting of vomiting /nausea (5 cases), moderate anemia (1 cases) and alopecia (5 cases). In this regard, there were no significant differences between the two groups (χ2=0.617, P>0.05). The positive rate of MMP-2 and FasL in the group A and group B after treatment were lower than before treatment, while the positive rate of Fas in group A and group B after treatment was significantly higher than before treatment (P<0.05). There were no significant differences of the positive rates of MMP-2, Fas and FasL in control group before and after treatment
(P>0.05).【Conclusion】Neoadjuvant chemotherapy is effective in the treatment of locally advanced cervical cancer. MMP-2, Fas and FasL cytokines are closely related to cervical cancer cells.
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Received: 03 July 2017
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(8): 1558-1560. |
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2017, Vol. 34 
