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| Effect of Human Urinary Kallikrein in Treatment of Acute Cerebral Infarction and its Effects on Brain Metabolites |
| ZHANG Yi-fan, WANG Mo-li, GUO Yun-guan et al |
| Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053 |
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Abstract 【Objective】To evaluate the effect of human kallidinogenase(HUK) on the changes of brain metabolites in patients with acute ischemic cerebral infarction (AIS) by magnetic resonance spectroscopy.【Methods】Fifty-seven patients diagnosed as AIS by MRI in 72 h were randomly divided into two groups. The control group was given routine basic therapy and symptomatic supportive care. The observation group was treated with HUK on the basis of the control group. The levels of N-acetyl aspartate (NAA) and creatine (Cr) in the brain were measured by magnetic resonance spectroscopy (MRS) before and after treatment. The NIHSS was performed by the National Institutes of Health, Improved Rankin scale (mRs) score, Barthel index (BI) to evaluate clinical efficacy.【Results】The values of NAA, NAA /Cr in peripheral infarcted area, NIHSS score and mRS were not significantly different between the two groups (P> 0.05) before the treatment. One week after treatment, the NAA and NAA/Cr in peripheral infarcted area of the two groups were higher than those before treatment (P<0.05).In the observation group, the increase of NAA and NAA/Cr in peripheral infarcted area was higher than that in the control group (P<0.05).In regard to the NIHSS scores of the two groups after treatment, the mRS score decreased and the BI index increased compared with those before treatment(P<0.05), and the improvement degree of the observation group was better than that of the control group (P<0.05).【Conclusion】HUK treatment can improve the metabolism and clinical function of the brain cells around the infarcted area in AIS patients, and protect the nerve cells.
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Received: 17 May 2017
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2017, Vol. 34 
