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| Establishment of Reference Intervals of Plasma D-dimer in Women During Third Trimester of Pregnancy in Hunan |
| MAO An-hua, XIANG Yue-yun, WANG Jian-hui, et al |
| Department of Clinical Laboratory, the Hunan Provincial Maternal and Child Health Hospital, Changsha, Hunan 410008 |
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Abstract 【Objective】To establish reference intervals for D-dimer in women of late pregnancy in Hunan area.【Methods】Six hundred and seventy-eight healthy singleton pregnancy women, 418 healthy twins or multiple pregnancy women(≥28 weeks)and 208 healthy non-pregnant women received Physical Examination in the hospital from January 2014 to March 2016 were selected. Automatic biochemical analyzer was used to detect the concentration of plasma D-dimer(D-dimer unit, DDU) by immune turbidimetric method.【Results】The plasma levels of D-dimer in third trimester of pregnancy were higher than those of non-pregnant women(P<0.05), the plasma D-dimer level of twins or multiple pregnancy women was significantly higher than that of the singleton pregnancy women in the same period of time (P<0.05). Late pregnant women plasma D- dimer ( D- dimer units, DDU) reference interval: single pregnancy group: 28~35 weeks <3.64 μg/mL; 36~39 weeks<6.12 μg/mL; 40~41weeks<6.84 μg/mL; twins /multiple pregnancy group: 28~31 weeks<6.26 μg/mL; 32~35 weeks<7.13 μg/mL; 36~39 weeks<8.00 μg/mL.【Conclusion】This study preliminarily established the reference interval of plasma D-dimer by immune turbidimetric method in late pregnancy women in Hunan Province, which is suitable for reference in the whole province.
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Received: 18 April 2017
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2017, Vol. 34 
