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| Expression of IL-1 β, GSTM1, hMLH1 in Gastric Carcinoma and its Relationship with Clinical Pathology |
| ZHAO Hai-bing, ZHAO Ling-na, YIN Ting-ting, et al |
| Department of Pathology, Taihu Hospital of Wuxi, Jiangsu 214044 |
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Abstract 【Objective】To study the expression of IL-1β, GSTM1 and hMLH1 in gastric carcinoma and its relationship with clinical pathology.【Methods】Two hundred patients with gastric carcinoma (gastric carcinoma group) and 200 patients with benign gastric lesions (control group) were enrolled in the study. The expression of IL-1β, GSTM1 and hMLH1 was detected, and its relationship with clinical pathology was analyzed.【Results】The rates of IL-1β(T/T), GSTM1 deletion and low expression of HhMLH1 in the gastric carcinoma group were significantly higher than those in the control group (P<0.05). Age>60 years old, tumor diameter <5cm and low tumor differentiation were strongly correlated with high expression rate of IL-1 βT/T genotype. Male and age >60 years old were much correlated with high rate of GSTM1 deletion. Tumor location and TNM stage Ⅲ~Ⅳwere highly correlated with low expression of hMLH1. Logistic regression analysis showed that IL-1β(T/T) (OR=3.124), GSTM1 deletion (OR=4.576) and low expression of hMLH1 (OR=7.534) were risks for the 5-years survival rate of patients with gastric carcinoma, and there was synergistic effect among the three genes (P<0.05, OR>1).【Conclusion】Expression of IL-1 βT/T genotype, GSTM1 deletion and low expression of hMLH1 are closely related to the development of gastric carcinoma. There is synergistic effect among the three genes. Carrying genes with interactions will increase the risk of gastric carcinoma and death.
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Received: 06 March 2017
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2017, Vol. 34 
