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| Effects of Long-term Use of Adefovir Dipivoxil on Renal Functions in Patients of Chronic Hepatitis B |
| ZHANG Peng, ZHANG Chang-jang, ZHU Yan, et al |
| Department of Infectious Diseases, Southwest Hospital, the Third Military Medical University, Chongqing 400038, China |
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Abstract 【Objective】To investigate the effects of long-term use of adefovir dipivoxil (ADV) on renal functions in patients of chronic hepatitis B (CHB).【Methods】A total of 317 patients with CHB who were treated with ADV (10 mg/d) alone or combined with oral administration of for more than 24 months were selected and divided into kidney injury group (118 cases)and non renal injury group (199 cases)according to the renal function damage.Serological, virological and renal function tests in the past two years were analyzed. By χ2 test, Binary Logistic Regression Analysis, ROC curve analysis and other statistical methods, the effects of elements including the gender, age, time of use ADV, ADV combined with other antiviral drugs, HBsAg, HBeAg, HBV, DNA, ALT, GLU and other factors on early renal injury were accordingly investigated.【Results】Chi-square test showed that: there was significant difference in age and ADV medication time, but there was no significant difference between the other factors; Binary Logistics Regression Analysis showed that: age and ADV medication time had significant effect on the dependent variable of early renal damage; ROC curve analysis showed that: age and ADV duration had a significant corresponding sensitivity on early renal injury, the relevant Youden's index was 0.616, 0.422.【Conclusion】Age and treatment time of ADV are risk factors of renal damage incidents; the age of 47.5 years old can be used as a critical reference year of kidney damage events; the time of ADV medication is 3.175 years, which can be used as the critical reference life events of early renal injury occurred.
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Received: 13 September 2017
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2017, Vol. 34 
