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Study on the Relationship between Hyperlipidemia and Progression and Prognosis of Acute Recurrent Pancreatitis |
LUO Fang |
People's Hospital of Jiajiang Leshan, Sichuan 614100 |
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Abstract 【Objective】To study the relationship between hyperlipidemia and the progression and prognosis of acute recurrent pancreatitis. 【Methods】A total of 110 patients with acute recurrent pancreatitis (ARP) were divided into the mild ARP group and the severe ARP group, according to the progression of disease. At the same time, 50 healthy persons were selected as the control group. The baseline data, blood lipid indexes, CRP levels, APACHEII score and mortality rate were compared between the two groups. Pearson correlation analysis was performed to analyze the relationship between blood lipid indexes and APACHEII score. 【Results】The levels of TG, HDL-C, LDL-C and CRP showed significant differences between groups (P<0.05). The APACHEII scores in the severe ARP were significantly higher than those in the mild ARP group before and after treatment (P<0.05). The mortality rates of the severe ARP group and the mild ARP group were 9.52% and 4.41%, respectively (P>0.05). Pearson correlation analysis showed that APACHEII score was related to TG, LDL-C and HLD-C (P<0.05). 【Conclusion】Hyperlipidemia is related to the severity of ARP. So, active treatment of ARP and simultaneous lipid-lowering intervention can effectively improve the prognosis of patients.
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Received: 12 December 2016
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[1]袁文清.高脂血症性急性胰腺炎临床特点及治疗[J].医学临床研究,2011,28(10):1970-1971. [2] 牛蕾,葛春.急性复发性胰腺炎与高脂血症的互为因果关系及临床特点[J].世界华人消化杂志,2016,24(30):4205-4210. [3] Yokoe M,Takada T, Mayumi T,et al.Japanese guidelines for the management of acute pancreatitis: Japanese Guidelines 2015[J].J Hepatobiliary Pancreat Sci,2015,22(6): 405-432. [4] 李邦一,张玫,和芳,等.新分级标准下血脂与急性胰腺炎病情严重程度的相关性[J].实用医学杂志,2015,31(16):2704-2706. [5] 周晓睛,杜宗汉,陈福敏,等.高脂血症对急性胰腺炎发病的影响[J].西部医学,2010,22(5):881-882. [6] 张帆,郭强,张渊智,等.高脂血症、微循环障碍与急性胰腺炎关系的探讨[J].胃肠病学和肝病学杂志,2011,20(3):275-278. [7] Bugdaci MS,Sokmen M,Zuhur SS,et al.Lipid profile changes and importance of low serum α-lipoprotein fraction (high-density lipoprotein) in cases with acute pancreatitis[J].Pancreas,2011,40(9):1241-1244. [8] 李志娟.急性胰腺炎严重程度与血脂代谢异常的相关性及其预后研究[J].临床内科杂志,2014,31(3):183-185. [9] 刘秀霞,费文萍.伴高脂血症的老年急性胰腺炎患者 C 反应蛋白的检测意义[J].湖南师范大学学报(医学版),2016,13(2):78-80. [10] 张静.BISAP评分联合促炎/抗炎细胞因子检测对重症急性胰腺炎预后的评估价值[J].解放军医药杂志,2016,8(2):62-65,73. [11] 杨宇龙,王农荣.高脂血症性重症急性胰腺炎降脂治疗与病情转归的关系[J].南昌大学学报(医学版),2012,52(1):56-58. [12] 潘刚,陈亚峰,蔡杰,等.老年高脂血症性急性胰腺炎临床特点及预后评估因素分析[J].临床军医杂志,2016,44(6):579-582. |
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